Evidence map›Paper›PMID 30048610›Full record

ArticleNeuron2018

Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior.

Ki-Jun Yoon, Guo-Li Ming, Hongjun Song

Open access · bronzeAbstract readComment
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. ALKBH5 demethylates the mProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  10. The role mMolecular brain · 2021
    Review
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  15. Article
  16. The mFrontiers in genetics · 2019
    Review
  17. The role of mRNA mCell & bioscience · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ki-Jun YoonDepartment of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Guo-Li MingDepartment of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hongjun SongDepartment of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: shongjun@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7M
Translational models of neurodevelopmental epigenetics and disease using human iPSCsP01NS097206 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HE, CHUAN · 2016 to 2020
$4.3M
Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0M
Deconstructing the hypothalmic ontogeny and plasticity via clonal analysisR21MH110160 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2016 to 2017
$444k
Development of forebrain organoid platform for modelling human cortical neurogenesisR21NS095348 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2015 to 2016
$294k
NIMH NIH HHS R01 MH105128NIMH NIH HHS R21 MH110160NINDS NIH HHS P01 NS097206NINDS NIH HHS R21 NS095348NINDS NIH HHS R35 NS097370
6 · The paper itself

Abstract

Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m

Indexed as

AdenosineMethyltransferasesAnimalsBrainMethylationRNA, MessengerAdenosineMethyltransferasesRNA, MessengerbehaviorepitranscriptomicsFTOgene expressionMettl14Mettl3N(6)-methyladenosine (m(6)A)stress

Identifiers

PMID30048610
PMCPMC6778836
OpenAlexW2883696354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.