Evidence map›Paper›PMID 30048513›Full record

ArticlePloS one2018

Cognitive behaviour treatment of co-occurring depression and generalised anxiety in routine clinical practice.

Roz Shafran, Abigail Wroe, Sasha Nagra, Eleni Pissaridou, Anna Coughtrey

Abstract readComparative Study
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Drug addiction: a curable mental disorder?Acta pharmacologica Sinica · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roz ShafranPopulation, Policy and Practice, University College London Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, United Kingdom.ORCID 0000-0003-2729-4961
Abigail WroeBerkshire Healthcare NHS Foundation Trust, Berkshire, United Kingdom.
Sasha NagraBerkshire Healthcare NHS Foundation Trust, Berkshire, United Kingdom.
Eleni PissaridouPopulation, Policy and Practice, University College London Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, United Kingdom.
Anna CoughtreyPopulation, Policy and Practice, University College London Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnxiety and depression are closely associated. However, they are typically treated separately and there is a dearth of information on tackling them together.

aimsThe study's purpose was to establish how best to treat co-occurring anxiety and depression in a routine clinical service-specifically, to compare cognitive behaviour therapy (CBT) focusing only on depression (CBT-D) to a broader CBT focusing on both depression and anxiety (CBT-DA).

methodCase notes of 69 patients with equally severe clinical levels of depression and anxiety seen in a routine clinical service were randomly selected to review from a pool of 990 patients. The mean age was 44.61 years (SD = 12.97). 65% of the sample were female and 88% reported their ethnicity white. The content of electronic records reporting techniques used and scores on a measure of depression (The Patient Health Questionnaire) and anxiety (The Generalized Anxiety Disorder Assessment) were reviewed to categorise therapy as CBT-D or CBT-DA.

resultsResults indicated significant overall improvement with CBT; 70% and 77% of the sample met criteria for reliable improvement on The Patient Health Questionnaire and The Generalized Anxiety Disorder Assessment respectively. Fewer patients who received CBT-DA met The Generalized Anxiety Disorder Assessment recovery criteria at the end of treatment than those who received CBT-D. Mean post treatment PHQ-9 and GAD-7 scores remained above threshold for those receiving CBT_DA but not those receiving CBT-D. There was no evidence suggesting CBT-DA was superior to CBT-D.

conclusionsIn patients with equally severe clinical levels of depression and anxiety, a broader treatment addressing both anxiety and depression does not appear to be associated with improved outcomes compared to treatment focused on depression.

Indexed as

Cognitive Behavioral TherapyAdultAgedAnxiety DisordersDepressive DisorderFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung Adult

Identifiers

PMID30048513
PMCPMC6062076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.