ArticlePLoS computational biology2018
OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 415 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
To Estimate the Efficacy of Botulinum Toxin A Injection Combing With Exoskeleton Robotic Assisted Gait Training in Stroke Patients With Spastic Stiff Knee Gait: Motor Function Performance and Neurophysiological Evaluation
Characterization and Clinical Trial of a Variable Friction Shoe, a New Paradigm of Reduced-constraint Locomotor Therapy for People Exhibiting Foot Drop Due to Stroke
Who cites it
415 citing papers in PubMed.
- The Effect of Minimalist Versus Motion Control Shoes on Patellofemoral Joint Forces in Adolescents With Patellofemoral Pain During Running: A Randomized Crossover Study.The American journal of sports medicine · 2026Trial
- Development of a support system for total hip arthroplasty: evaluation of lower limb loads using virtual and dummy human body models.International journal of computer assisted radiology and surgery · 2026Article
- Deep learning models detect neuromuscular disease and quantify functional impairment from video-derived biomechanics data.bioRxiv : the preprint server for biology · 2026Article
- Application of Deep Learning-Based Markerless Pose Estimation in a 3D Exergame System for Knee Osteoarthritis Exercise Management: Development and Preliminary Evaluation.Sensors (Basel, Switzerland) · 2026Article
- Towards a Conceptual Framework for Mechanical Dose in Skeletal Muscle: Integrating Mechanobiology and Resistance Training.Journal of functional morphology and kinesiology · 2026Review
- Co-optimized volumetric muscle design for large dynamic deformations in versatile biohybrid robots.Nature communications · 2026Article
- Value-Gradient Generalist Design of Muscle-Tendon Parameters for Cross-Terrain Musculoskeletal Locomotion.Biomimetics (Basel, Switzerland) · 2026Article
- Simulation study of exoskeleton-musculoskeletal coupling for exoskeleton assistance via multi-agent reinforcement learning.Medical & biological engineering & computing · 2026Article
- Real-Time Physiological Fatigue Prediction for Human-Robot Collaborative Manufacturing Using Wearable Sensor Fusion and Hybrid Deep Learning: An In Silico Digital Twin Study.Sensors (Basel, Switzerland) · 2026Article
- Methods for assessing core muscle co-activation in the lumbar region: a narrative review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- Study on the Influence of Rotation Axis Misalignment of the Exoskeleton Knee Joint on Human Knee Joint Torque.Sensors (Basel, Switzerland) · 2026Article
- Multilevel Determinants of Acromiohumeral Distance Within a Systems-Based Functional Morphology Framework and Their Implications for Personalized Neuromusculoskeletal Modelling.Journal of functional morphology and kinesiology · 2026Article
- Subject-Specific Finite Element Analysis of the Foot Using a Simplified Parametric Bone Model from Weight-Bearing Radiographs.Annals of biomedical engineering · 2026Article
- Novel Use of Inertial Measurement Units to Drive Inverse Kinematics Model to Estimate Motion During Military Parachute Tethered Tandem Bundle Operations.Annals of biomedical engineering · 2026Article
- GaitDynamics: a generative foundation model for analyzing human walking and running.Nature biomedical engineering · 2026Article
- Functional Differences in Muscle Architecture Across the Pelvis and Hind Limb of Primates.American journal of biological anthropology · 2026Article
- DeepGaitLab: Accurate and Flexible Markerless Motion Tracking Powered by Synthetic Data.Research square · 2026Article
- Estimating Muscle Parameters via Hierarchical Bayesian Neuromechanics.bioRxiv : the preprint server for biology · 2026Article
- Effect of muscle atrophy on fracture healing: insights from a tibial musculoskeletal-finite element model.Biomechanics and modeling in mechanobiology · 2026Article
355 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Movement is fundamental to human and animal life, emerging through interaction of complex neural, muscular, and skeletal systems. Study of movement draws from and contributes to diverse fields, including biology, neuroscience, mechanics, and robotics. OpenSim unites methods from these fields to create fast and accurate simulations of movement, enabling two fundamental tasks. First, the software can calculate variables that are difficult to measure experimentally, such as the forces generated by muscles and the stretch and recoil of tendons during movement. Second, OpenSim can predict novel movements from models of motor control, such as kinematic adaptations of human gait during loaded or inclined walking. Changes in musculoskeletal dynamics following surgery or due to human-device interaction can also be simulated; these simulations have played a vital role in several applications, including the design of implantable mechanical devices to improve human grasping in individuals with paralysis. OpenSim is an extensible and user-friendly software package built on decades of knowledge about computational modeling and simulation of biomechanical systems. OpenSim's design enables computational scientists to create new state-of-the-art software tools and empowers others to use these tools in research and clinical applications. OpenSim supports a large and growing community of biomechanics and rehabilitation researchers, facilitating exchange of models and simulations for reproducing and extending discoveries. Examples, tutorials, documentation, and an active user forum support this community. The OpenSim software is covered by the Apache License 2.0, which permits its use for any purpose including both nonprofit and commercial applications. The source code is freely and anonymously accessible on GitHub, where the community is welcomed to make contributions. Platform-specific installers of OpenSim include a GUI and are available on simtk.org.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.