ArticleAging2018
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and
Open access · greenAbstract read
In one paragraph
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 514 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
514citing papers in PubMed, 1 pooled it
17.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
514 citing papers in PubMed, 1 synthesis or guideline pooled it, 813 citations in OpenAlex.
- Chemical and climatic environmental exposures and epigenetic aging: A systematic review.Environmental research · 2025Pooled it
- Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy.Nature communications · 2026Trial
- S-adenosylmethionine as an epigenetic treatment of depression in adults with childhood trauma.Epigenomics · 2026Trial
- Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial).Scientific reports · 2025Trial
- Trial
- Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood.Epigenetics · 2026Article
- Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.GeroScience · 2026Article
- Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors.GeroScience · 2026Article
- Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers.Epigenetics · 2026Article
- Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging.GeroScience · 2026Article
- Protracted Fate Acquisition and Epigenetic De-Aging During Induced Neural Stem Cell Conversion of Human Blood Cells.Aging cell · 2026Article
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- Exploring Epigenetic Aging and Cognitive Change in Middle Adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- System-Specific Epigenetic Aging Signatures in Autistic Adults.bioRxiv : the preprint server for biology · 2026Article
- Duration of smoking cessation and DNA methylation aging clocks among US adults: potential reversibility of smoking-induced biological aging.GeroScience · 2026Article
- Epigenetic clocks can differentiate between exogenous and endogenous skin ageing.Clinical epigenetics · 2026Article
- Effects of a randomized controlled trial of unconditional cash transfers on epigenetic measures of ageing and cognition in children and mothers.Nature human behaviour · 2026Article
- Article
- Article
454 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 13 institutions in 3 countries.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Junko OshimaDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
George M MartinDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Austin QuachDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Howard CohenElizabeth House, Warlingham, Surrey CR6 9LF, United Kingdom.
Sarah FeltonDepartment of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LJ, United Kingdom.
Mieko MatsuyamaDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Donna LoweRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom.
Sylwia KabacikRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Alex P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Anna MaierhoferInstitute of Human Genetics, Julius Maximilians University, Würzburg, Germany.
Julia FlunkertInstitute of Human Genetics, Julius Maximilians University, Würzburg, Germany.
Abraham AvivCenter of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.
Lifang HouCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andrea A BaccarelliLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Yun LiDepartments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
James D StewartDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Shigemi MatsuyamaDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Kenneth RajRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom.
Public Health England · GBUniversity of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USCase Western Reserve University · USChiba University · JPColumbia University · USFred Hutch Cancer Center · USJackson Memorial Hospital · USNational Institutes of Health · USOxford University Hospitals NHS Trust · GBRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityRutgers New Jersey Medical SchoolUniversity of Washington · US
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MASON, SARAH · 2016 to 2025
$38.2MInternational Registry of Werner SyndromeR01CA210916 · NCI · UNIVERSITY OF WASHINGTON · PI JUNKO OSHIMA · 2016 to 2026
$3.8MValidation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4MLeukocyte Telomere Length and Cardiovascular Disease in Jackson Heart StudyR01HL116446 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI AVIV, ABRAHAM, REINER, ALEXANDER P · 2013 to 2016
$3.1MEpigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0MThe epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) NetworkU34AG051425 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE · 2015 to 2017
$954kNCI NIH HHS R01 CA210916NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL116446NIA NIH HHS U01 AG060908NIA NIH HHS U34 AG051425NIEHS NIH HHS R01 ES020836NIGMS NIH HHS U54 GM115428
Abstract
DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts and other cell types used in
Indexed as
Skin Physiological PhenomenaAgingBiological ClocksBlood CellsCellular SenescenceDNA MethylationEpigenesis, GeneticFetal BloodFibroblastsGene Expression RegulationHumansProgeriaDNA methylationepigeneticsfibroblastsHutchinson-Gilfordprogeria
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.