Evidence map›Paper›PMID 30048219›Full record

ReviewAnnual review of virology2018

Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.

Patrick T Dolan, Zachary J Whitfield, Raul Andino

Abstract readReview
In one paragraph

Review in Annual review of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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  11. Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025
    Review
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  19. Review
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick T DolanDepartment of Biology, Stanford University, Stanford, California 94305, USA.
Zachary J WhitfieldDepartment of Microbiology and Immunology, University of California, San Francisco, California 94143, USA; email: raul.andino@ucsf.edu.
Raul AndinoDepartment of Microbiology and Immunology, University of California, San Francisco, California 94143, USA; email: raul.andino@ucsf.edu.

Funding

Unbiased Functional Characterization of Enterovirus-Host InteractionsP01AI091575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2011 to 2015
$10.5M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
RECOMBINANT PICORNAVIRUSES AS AIDS VACCINESR01AI036178 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDINO, RAUL · 1994 to 2011
$3.6M
The Role of Cellular Chaperones in RNA Virus InfectionF32GM113483 · NIGMS · STANFORD UNIVERSITY · PI DOLAN, PATRICK TIMOTHY · 2015 to 2017
$162k
NIAID NIH HHS P01 AI091575NIAID NIH HHS R01 AI036178NIAID NIH HHS T32 AI060537NIGMS NIH HHS F32 GM113483
6 · The paper itself

Abstract

RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and frequent recombination. They rapidly adapt to environmental changes, such as shifts in immune pressure or pharmacological challenge. The evolution of RNA viruses has been brought into new focus with the recent developments of genetic and experimental tools to explore and manipulate the evolutionary dynamics of viral populations. These studies have uncovered new mechanisms that enable viruses to overcome evolutionary challenges in the environment and have emphasized the intimate relationship of viral populations with evolution. Here, we review some of the emerging viral and host mechanisms that underlie the evolution of RNA viruses. We also discuss new studies that demonstrate that the relationship between evolutionary dynamics and virus biology spans many spatial and temporal scales, affecting transmission dynamics within and between hosts as well as pathogenesis.

Indexed as

Adaptation, BiologicalBiological EvolutionHost-Pathogen InteractionsPopulation DynamicsRNA Virusesgenetic robustnesspathogenesispopulation geneticsquasispeciesrecombinationwithin-host evolution

Identifiers

PMID30048219
PMCPMC13283306

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.