ArticleHepatology (Baltimore, Md.)2019
Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice.
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Article in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
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Who cites it
49 citing papers in PubMed, 102 citations in OpenAlex.
- Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse.Archives of toxicology · 2026Article
- The emerging role of the Hippo signaling pathway in interorgan crosstalk.The FEBS journal · 2026Review
- Sevoflurane ameliorates cerebral ischemia-reperfusion injury by modulating mitochondrial dynamics and attenuating apoptosis via Shh-YAP1 signaling pathway.Molecular brain · 2026Article
- Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice.Acta pharmacologica Sinica · 2025Article
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- Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.Signal transduction and targeted therapy · 2025Review
- An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.Nature communications · 2025Article
- Harnessing the UDP-G/P2YActa pharmaceutica Sinica. B · 2025Article
- Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives.Frontiers in endocrinology · 2025Review
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- Regulation of hepatic xenosensor function by HNF4alpha.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Fenofibrate-promoted hepatomegaly and liver regeneration are PPARActa pharmaceutica Sinica. B · 2024Article
- Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin-Induced Liver Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals.Archives of toxicology · 2024Article
- The integrated analysis of gut microbiota and metabolome revealed steroid hormone biosynthesis is a critical pathway in liver regeneration after 2/3 partial hepatectomy.Frontiers in pharmacology · 2024Article
- LCN2 depletion aggravates sepsis-induced liver injury by regulating PTGS2-dependent ferroptosis.International journal of medical sciences · 2024Article
- Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.CNS neuroscience & therapeutics · 2023Article
- Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation.Acta pharmacologica Sinica · 2023Article
- Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice.Parasites & vectors · 2023Article
- Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor.Molecular medicine (Cambridge, Mass.) · 2023Article
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Authors and funding
18 authors at 7 institutions in 2 countries.
Yiming JiangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Dechun FengLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Xiaochao MaDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA.
Shicheng FanGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Yue GaoGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Kaili FuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Ying WangSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Jiahong SunGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Xinpeng YaoGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Conghui LiuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Huizhen ZhangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Leqian XuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Aiming LiuMedical School of Ningbo University, Ningbo, China.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Yingzi YangHarvard School of Dental Medicine, Boston, MA.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Min HuangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Huichang BiGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Sun Yat-sen University · CNCenter for Cancer Research · USHarvard University · USNational Institute on Alcohol Abuse and Alcoholism · USNational Institutes of Health · USNingbo University · CNUniversity of Pittsburgh · US
Funding
Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9MPathogenesis and Novel Therapeutic Targets of Steatotic Liver Disease and CancerZIAAA000369 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GAO, BIN · 2009 to 2025
$23.4MMolecular mechanisms of liver injury, repair, and immunityZIAAA000368 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GAO, BIN · 2009 to 2023
$16.1MCellular and molecular mechanism of Hippo signaling in suppressing liver tumor formationR01CA222571 · NCI · HARVARD MEDICAL SCHOOL · PI YANG, YINGZI · 2018 to 2022
$1.9MImmunity, liver injury and repairZ01AA000368 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GAO, BIN · 2002 to 2008
$1.2MIntramural NIH HHS Z01 AA000368Key Laboratory Foundation of Guangdong ProvinceKey Laboratory Foundation of Guangdong Province 2017B030314030National Key Research and Development Program 2011A060901014National Key Research and Development Program 2017YFC0909303National Key Research and Development Program 2017YFE0109900National Natural Science Foundation of China 81320108027National Natural Science Foundation of China 81522047National Natural Science Foundation of China 81573489National Natural Science Foundation of China 81730103National Natural Science Foundation of China : B16047Natural Science Foundation of GuangdongNatural Science Foundation of Guangdong 2015A030313124Natural Science Foundation of Guangdong 2017A030311018NCI NIH HHS R01 CA222571the 111 project B16047
Abstract
Activation of pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, is known to induce liver enlargement, but the molecular signals and cell types responding to PXR-induced hepatomegaly remain unknown. In this study, the effect of PXR activation on liver enlargement and cell change was evaluated in several strains of genetically modified mice and animal models. Lineage labeling using AAV-Tbg-Cre-treated Rosa26
Indexed as
Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell DifferentiationHepatocytesLiverMaleMiceMice, Inbred C57BLMice, KnockoutOrgan SizePregnane X ReceptorYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsPregnane X ReceptorYap1 protein, mouseYAP-Signaling Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.