ReviewBritish journal of pharmacology2018
The signalling roles of sphingosine-1-phosphate derived from red blood cells and platelets.
Review in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Potential Mechanisms of Platelet Dysfunction and Bleeding in Acid Sphingomyelinase Deficiency.Cells · 2026Review
- Erythrocytes as a Source of Exerkines.International journal of molecular sciences · 2025Review
- Time Course of Plasma Proteomic and Oxylipin Changes Induced by LPS Challenge and Modulated by Antioxidant Supplementation in a Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
- Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics.Scientific reports · 2025Article
- Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management.Drugs · 2024Review
- Preservation of recipient plasma sphingosine-1-phosphate levels reduces transfusion-related acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target.Cancer cell international · 2024Review
- How do sphingosine-1-phosphate affect immune cells to resolve inflammation?Frontiers in immunology · 2024Review
- Bleeding and Thrombosis in Multiple Myeloma: Platelets as Key Players during Cell Interactions and Potential Use as Drug Delivery Systems.International journal of molecular sciences · 2023Review
- Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions.Cellular and molecular life sciences : CMLS · 2022Article
- YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury.Stem cell reports · 2022Article
- Review
- Spns2 Transporter Contributes to the Accumulation of S1P in Cystic Fibrosis Human Bronchial Epithelial Cells.Biomedicines · 2021Article
- Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19.International journal of molecular sciences · 2020Review
- Effects of sphingolipids overload on red blood cell properties in Gaucher disease.Journal of cellular and molecular medicine · 2020Article
- Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades.Oxidative medicine and cellular longevity · 2020Article
- The signalling roles of sphingosine-1-phosphate derived from red blood cells and platelets.British journal of pharmacology · 2018Review
- Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.The Journal of biological chemistryArticle
- Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingosine-1-phosphate (S1P) is an essential, bioactive lysophospholipid mediator that regulates various physiological functions such as lymphocyte trafficking, inflammation and behavioural characteristics of the vascular system. S1P signalling is mediated via a family of five GPCRs, which are expressed in various cell types and tissues. S1P concentration is maintained in a gradient through the activity of S1P degrading enzymes, and this gradient is critical for lymphocyte egress. To exert its extracellular signalling roles, S1P must be secreted out of the cells by protein transporters. The recent discovery of S1P transporters has shed light on the sources of S1P. However, these transporters still need to be clarified as they are important in defining the S1P gradient for lymphocyte recirculation and the source of S1P for maintenance of blood vessels. Here, we review the current understanding of S1P sources, highlighting the roles of S1P transporters with an emphasis on haematopoietic cells as a major source of circulatory S1P.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.