Evidence map›Paper›PMID 30047784›Full record

Trial reportThe Australian and New Zealand journal of psychiatry2018

The impact of substance use disorders on recovery from bipolar depression: Results from the Systematic Treatment Enhancement Program for Bipolar Disorder psychosocial treatment trial.

Alexandra K Gold, Amy T Peters, Michael W Otto, Louisa G Sylvia, Pedro Vieira da Silva Magalhaes, Michael Berk, Darin D Dougherty, David J Miklowitz, Ellen Frank, Andrew A Nierenberg and 1 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Australian and New Zealand journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Alexandra K Gold1 Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Amy T Peters2 Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
Michael W Otto1 Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Louisa G Sylvia3 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Pedro Vieira da Silva Magalhaes5 Departamento de Psiquiatria e Medicina Legal, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Michael Berk6 Impact Strategic Research Centre, Deakin University, Melbourne, VIC, Australia.
Darin D Dougherty3 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
David J Miklowitz8 Department of Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.
Ellen Frank9 Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew A Nierenberg3 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Thilo Deckersbach3 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Massachusetts General Hospital · USBoston University · USHarvard University · USUniversidade Federal do Rio Grande do Sul · BRUniversity of California, Los Angeles · USUniversity of Illinois Chicago · USUniversity of Melbourne · AUUniversity of Pittsburgh · US

Funding

TREATMENT OF BIPOLAR DISORDER-278980001N01MH080001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · 1998 to 2003
$5.3M
NIMH NIH HHS N01 MH080001
6 · The paper itself

Abstract

objectiveUp to 60% of patients with bipolar disorder develop a substance use disorder during their lifetime. The purpose of this paper was to assess the impact of substance use disorders on depression recovery among bipolar patients randomly assigned to different psychotropic medications and psychosocial interventions. We hypothesized that patients with a comorbid substance use disorder would benefit less from psychotherapy regardless of treatment intensity/length compared to patients without a comorbid substance use disorder.

methodWe conducted post hoc analyses among bipolar disorder patients ( n = 270) with and without comorbid substance use disorders enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder randomized psychosocial intervention trial. All patients entered during or shortly after the onset of a bipolar depressive episode. Logistic regression and Cox proportional hazard models were used to assess whether current or past substance use disorders moderated the response of patients to intensive psychosocial intervention or brief psychoeducation with collaborative care, operationalized as full recovery from an episode of bipolar depression.

resultsCurrent comorbid substance use disorders significantly predicted likelihood of recovery (odds ratio = 2.25, p = 0.025) and time to recovery (odds ratio = 1.71, p = 0.006) from bipolar depression. We found that 74.5% of patients with a current substance use disorder, compared to 56.5% without a current substance use disorder, recovered from bipolar depression. Past substance use disorders did not predict likelihood of recovery or time to recovery. Current substance use disorders did not significantly moderate response to intensive psychotherapy versus collaborative care.

conclusionContrary to our hypotheses, bipolar disorder participants with a current comorbid substance use disorder were more likely to recover from psychosocial treatment for bipolar depression than patients without a current comorbid substance use disorder. If this finding is replicated, it has implications for the ordering of treatment for patients with comorbid bipolar disorder and substance use disorders.

Indexed as

AdolescentAdultBipolar DisorderCombined Modality TherapyComorbidityFemaleHumansMaleMiddle AgedPsychotherapyPsychotropic DrugsSubstance-Related DisordersTreatment OutcomeUnited StatesYoung AdultPsychotropic Drugsalcohol use disordersBipolar disorderdrug use disorderspsychotherapysubstance use disorders

Identifiers

PMID30047784
PMCPMC6778400
OpenAlexW2884715527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.