ArticleColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2019
Prophylactic closed-incision negative-pressure wound therapy is associated with decreased surgical site infection in high-risk colorectal surgery laparotomy wounds.
Article in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03716687 (Prophylactic Negative Pressure Wound Therapy for High Risk Laparotomy Wounds. Randomized Prospective Clinical Trial.), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Negative Pressure Wound Therapy for High Risk Laparotomy Wounds. Randomized Prospective Clinical Trial.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of Prophylactic Incisional Negative Pressure Wound Therapy on Surgical Site Infection After Emergency Laparotomy: An Updated Meta-Analysis With Trial Sequential Analysis.World journal of surgery · 2026Pooled it
- The use of negative pressure wound therapy following stoma reversal: a systematic review and meta-analysis of randomized controlled trials.International journal of colorectal disease · 2025Pooled it
- Surgical site infection prevention and management in immunocompromised patients: a systematic review of the literature.World journal of emergency surgery : WJES · 2021Pooled it
- An integrated, wearable, tubeless micro-negative pressure system for closed incision management: a translational preclinical and clinical study.Frontiers in medicine · 2026Article
- Negative Pressure Wound Therapy With Instillation and Closed Incision Negative Pressure Therapy Use in South Africa: Expert Panel Recommendations.International wound journal · 2025Article
- Article
- Review
- Incisional Negative Pressure Wound Therapy for Wounds in Patients with Lower Intestinal Perforations.Journal of the anus, rectum and colon · 2024Article
- Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications.Frontiers in nephrology · 2024Article
- Prophylactic negative pressure wound therapy in patients with closed surgical wound: An integrative review.Turkish journal of surgery · 2023Review
- Prophylactic effect of negative-pressure wound therapy and delayed sutures against incisional-surgical site infection after emergency laparotomy for colorectal perforation: A multicenter retrospective cohort study.Annals of gastroenterological surgery · 2023Article
- Cost-Utility Analysis of the Caresyntax Platform to Identify Patients at Risk of Surgical Site Infection Undergoing Colorectal Surgery.PharmacoEconomics - open · 2023Article
- Closed Incision Negative Pressure Therapy versus Standard of Care in Reduction of Surgical Site Complications: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2023Article
- Negative Pressure Wound Therapy Prevents Hernia Recurrence in Simultaneous Ventral Hernia Repair and Panniculectomy.Plastic and reconstructive surgery. Global open · 2022Article
- Prophylactic incisional negative pressure wound therapy for gynaecologic malignancies.International wound journal · 2022Article
- Use of Closed Incision Negative Pressure Therapy (ciNPT) in Breast Reconstruction Abdominal Free Flap Donor Sites.Journal of clinical medicine · 2021Article
- Hybrid Use of Negative Pressure Therapy in the Management of Partial Wound Closure After Girdlestone Procedure.Cureus · 2020Article
- Closed incision negative pressure therapy following abdominoplasty after breast reconstruction with deep inferior epigastric perforator flaps.International wound journal · 2020Article
- Review
- Silver in Wound Care-Friend or Foe?: A Comprehensive Review.Plastic and reconstructive surgery. Global open · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSurgical site infection in colorectal surgery is associated with significant healthcare costs, which may be reduced by using a closed-incision negative-pressure therapy device. The aim of this study was to assess the impact of closed-incision negative-pressure therapy on the incidence of surgical site infection.
methodIn this retrospective cohort study we evaluated all patients who had undergone high-risk open colorectal surgery at a single tertiary care centre from 2012 to 2016. We compared the incidence of surgical site infection between those receiving standard postoperative wound care between 2012 and 2014 and those receiving closed-incision negative-pressure therapy via a customizable device (Prevena Incision Management System, KCI, an Acelity company, San Antonio, Texas, USA) between 2014 and 2016. A validated surgical site infection risk score was used to create a 1:1 matched cohort subset.
resultsNegative pressure therapy was used in 77 patients and compared with 238 controls. Negative pressure patients were more likely to have a stoma (92% vs 48%, P < 0.01) and to be smokers (33% vs 15%, P < 0.01). Surgical site infection was higher in control patients (15%, n = 35/238) compared with negative pressure patients (7%, n = 5/77) (P = 0.05). On regression analysis, negative pressure therapy was associated with decreased surgical site infection (OR 0.27; 95% CI 0.09-0.78). These differences persisted in the matched analysis.
conclusionNegative pressure therapy was associated with decreased surgical site infection. Negative pressure therapy offers significant potential for quality improvement.
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