ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Association of Polygenic Risk for Attention-Deficit/Hyperactivity Disorder With Co-occurring Traits and Disorders.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis.Scientific reports · 2021Pooled it
- Polygenic risk scores indicates genetic overlap between peripheral pain syndromes and chronic postsurgical pain.Neurogenetics · 2020Trial
- The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders.Drug and alcohol dependence · 2018Trial
- Polygenic risk score for neurodevelopmental disorders and cognitive impairment at long-term follow-up of first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- ADHD and intelligence polygenic scores associations with developmental dimensions in children with attention, learning and memory difficulties.European child & adolescent psychiatry · 2026Article
- Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style.Translational psychiatry · 2026Article
- Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study.BMC psychiatry · 2026Article
- ADHD remote technology and ADHD transition: predicting and preventing negative outcomes (ART-transition) - an adolescent prospective cohort study protocol.BMC psychiatry · 2025Article
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples.Journal of neurodevelopmental disorders · 2025Article
- Article
- Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review.Neuroscience applied · 2025Article
- Adult ADHD and comorbid anxiety and depressive disorders: a review of etiology and treatment.Frontiers in psychiatry · 2025Review
- Self-rated costs and benefits of conventional and alternative adult ADHD treatments.Scientific reports · 2024Article
- The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study.Translational psychiatry · 2024Article
- Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Psychiatry research · 2024Article
- Factors associated with anxiety disorder comorbidity.Journal of affective disorders · 2023Article
- Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.European archives of psychiatry and clinical neuroscience · 2023Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA recent large-scale mega genome-wide association study identified, for the first time, genetic variants at 12 loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). In this study we use a powerful polygenic approach, with polygenic scores derived from the genome-wide association study, to investigate the etiological overlap between ADHD and frequently co-occurring traits and disorders.
methodsPolygenic risk scores for ADHD derived from the mega genome-wide association study (20,183 cases and 35,191 control subjects) were computed in a large-scale adult population sample (N = 135,726) recruited by the UK Biobank. Regression analyses were conducted to investigate whether polygenic risk for ADHD is associated with related traits and disorders in this population sample. The effects of sex were investigated via inclusion of an interaction term in the models.
resultsPolygenic risk for ADHD significantly and positively predicted body mass index (R
conclusionsOur findings suggest that common genetic variation underlying risk for clinically diagnosed ADHD also contributes to higher body mass index, neuroticism, anxiety and depressive disorders, alcohol and nicotine use, risk taking, and lower general cognitive ability in the general population. These findings suggest that the co-occurrence of several traits with ADHD is partly explained by the same common genetic variants.
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