ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
The Startle-Evoked Potential: Negative Affect and Severity of Pathology in Anxiety/Mood Disorders.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Health anxiety amplifies fearful responses to illness-related imagery.Scientific reports · 2024Article
- End-Tidal COApplied psychophysiology and biofeedback · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- Health anxiety is associated with fearful imagery of contracting COVID-19: An experimental study.Journal of affective disorders · 2022Article
- Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
- Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.Journal of abnormal psychology · 2021Article
- RDoC at 10: changing the discourse for psychopathology.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Transdiagnostic trauma severity in anxiety and mood disorders: Functional brain activity during emotional scene processing.Psychophysiology · 2020Article
- Aging changes in protective balance and startle responses to sudden drop perturbations.Journal of neurophysiology · 2019Article
- Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level: A Pilot Study.Frontiers in human neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe National Institute of Mental Health Research Domain Criteria initiative encourages a search for dimensional biological measures of psychopathology unconstrained by current diagnostic categories. Consistent with this aim, the presented research studies a large sample of anxiety and mood disorder patients, assessing differences in principal diagnoses and comorbidity patterns, clinicians' ratings, and questionnaire measures of negative affect and life dysfunction as they relate to a potential brain marker of pathology: the amplitude of the event-related potential (ERP) elicited by a startle-evoking stimulus.
methodsPatients seeking evaluation or treatment for anxiety and mood disorders (N = 208) participated in two tasks at the University of Florida (Gainesville, FL): 1) imagining emotional and neutral events and 2) viewing emotional and neutral pictures while acoustic startle probes were presented and the ERP was recorded. For a comparison patient group (N = 120), startle probes were administered and ERPs recorded at the University of Greifswald (Greifswald, Germany) while performing the same imagery task.
resultsReduced positive amplitude of a centroparietal startle-evoked ERP (156-352 ms after onset) significantly predicted higher questionnaire scores of anxiety/depression, reports of increased life dysfunction, greater comorbidity, and clinician ratings of heightened severity and poorer prognosis. The effect was general across principal diagnoses, found for both the Florida and German samples, and consistent in pattern despite differences in the tasks administered.
conclusionsThe startle-evoked ERP reliably predicts severity and breadth of psychopathology, independent of task context. It is a potential significant contributor to a needed array of biological measures that might improve classification of anxiety and mood disorders.
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