Evidence map›Paper›PMID 30047416›Full record

ReviewHematology/oncology clinics of North America2018

Haploidentical Donor Bone Marrow Transplantation for Severe Aplastic Anemia.

Amy E DeZern, Robert A Brodsky

Open access · greenAbstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy E DeZernDivision of Hematologic Malignancies, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 3M87, Baltimore, MD 21287-0013, USA. Electronic address: Adezern1@jhmi.edu.
Robert A BrodskyDivision of Hematology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 1025, Baltimore, MD 21205, USA.
Johns Hopkins University · US

Funding

Advancing Diagnostics and Therapeutics in Bone Marrow FailureK23HL123601 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DEZERN, AMY E · 2014 to 2017
$637k
NHLBI NIH HHS K23 HL123601
6 · The paper itself

Abstract

Hematopoietic stem cell transplantation (bone marrow transplantation [BMT]) is the only curative treatment of severe aplastic anemia. BMT from an human leukocyte antigen (HLA)-matched sibling donor is the standard of care for young patients; immunosuppressive therapy is used for older patients or those lacking matched sibling donors. Patients with refractory or relapsed disease are increasingly treated with HLA haploidentical BMT. Historically, haploidentical BMT led to high rates of graft rejection and graft-versus-host disease. High-dose post transplant cyclophosphamide, which mitigates the risk of graft-versus-host disease, is a major advance. This article provides an overview of the haploidentical BMT approach in severe aplastic anemia.

Indexed as

Anemia, AplasticBone Marrow TransplantationSiblingsTissue DonorsGraft vs Host DiseaseHumansImmunosuppression TherapyTransplantation ConditioningTransplantation, HomologousCyclophosphamideGraft versus host diseaseHaploidentical transplantSevere aplastic anemia

Identifiers

PMID30047416
PMCPMC6063510
OpenAlexW2807098454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.