ArticleBrain and behavior2018
Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Cause or effect: Altered brain and network activity in cervical dystonia is partially normalized by botulinum toxin treatment.NeuroImage. Clinical · 2019Trial
- Striatal network dysfunction underlying speech impairment in early Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Technical considerations of functional MRI in deep brain stimulation: recent advances and future perspectives.NeuroImage · 2026Review
- Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.Journal of clinical medicine · 2026Article
- Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem.NPJ Parkinson's disease · 2024Review
- Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Continuous theta burst stimulation over right cerebellum for speech impairment in Parkinson's disease: study protocol for a randomized, sham-controlled, clinical trial.Frontiers in aging neuroscience · 2023Article
- Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit.PLoS computational biology · 2023Article
- Semantic fluency deficits and associated brain activity in Parkinson's disease with mild cognitive impairment.Brain imaging and behavior · 2022Article
- Subcortical and hippocampal brain segmentation in 5-year-old children: Validation of FSL-FIRST and FreeSurfer against manual segmentation.The European journal of neuroscience · 2022Article
- Characterization of Mild and Moderate Dysarthria in Parkinson's Disease: Behavioral Measures and Neural Correlates.Frontiers in aging neuroscience · 2022Article
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Speech dysfunction, cognition, and Parkinson's disease.Progress in brain research · 2022Review
- The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data.Brain imaging and behavior · 2021Article
- Characterizing resting-state networks in Parkinson's disease: A multi-aspect functional connectivity study.Brain and behavior · 2021Article
- Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study.Human brain mapping · 2021Article
- Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- The Effect of SPEAK OUT! and The LOUD Crowd on Dysarthria Due to Parkinson's Disease.American journal of speech-language pathology · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
introductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life-impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole-brain resting-state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.
methodsResting-state data from 89 right-handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls ("OHC"), 42 PD patients without speech impairment ("PDN"), and 35 PD subjects with speech impairment ("PDSI"). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III speech item scores ("0" vs. "1-4"). Whole-brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group-averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t-tests were performed to determine differences between the three groups using a voxel-wise threshold of p < 0.001 and cluster-extent threshold of 272 mm
resultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.
conclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.
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