Evidence map›Paper›PMID 30047080›Full record

ArticleMaternal and child health journal2018

Progress Toward Eliminating Mother to Child Transmission of HIV in Kenya: Review of Treatment Guidelines Uptake and Pediatric Transmission Between 2013 and 2016-A Follow Up.

Ruby Angeline Pricilla, Melinda Brown, Catherine Wexler, May Maloba, Brad J Gautney, Sarah Finocchario-Kessler

Open access · hybridAbstract read
In one paragraph

Article in Maternal and child health journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ruby Angeline PricillaDepartment of Community Medicine, Low Cost Effective Care Unit, Christian Medical College, Schell Eye Hospital Campus, Vellore, Tamil Nadu, India. rubykarl@yahoo.com.ORCID http://orcid.org/0000-0001-7835-6371
Melinda BrownDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Catherine WexlerDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
May MalobaGlobal Health Innovations, Kansas City, USA.
Brad J GautneyGlobal Health Innovations, Kansas City, USA.
Sarah Finocchario-KesslerDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
University of Kansas Medical Center · USHealth Innovations (United States) · USChristian Medical College, Vellore · IN

Funding

Piloting at-birth point of care HIV testing strategies in KenyaR01HD076673 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KESSLER, SARAH FINOCCHARIO · 2013 to 2017
$3.4M
Adapting the HITSystem to Support PMTCT Retention and ART AdherenceR34MH107337 · NIMH · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KESSLER, SARAH FINOCCHARIO · 2015 to 2017
$636k
National Institute of Mental Health R34MH107337National Institutes of Child Health and Development R01HD076673NICHD NIH HHS R01 HD076673NIMH NIH HHS R34 MH107337
6 · The paper itself

Abstract

Background Prevention of mother to child transmission of HIV (PMTCT) services are critical to achieve national and global targets of 90% antiretroviral therapy (ART) coverage in PMTCT, and mother to child transmission rates less than 5%. In 2012, Kenya adopted WHO's recommended ART regimen for PMTCT "Option B+". Aims This study assesses progress made in adopting these new guidelines and associated outcomes. Methods We analysed programmatic data of 2604 mother-infant pairs enrolled in the HIV Infant Tracking System (HITSystem) at four government hospitals in Kenya between January, 2013 and December, 2016. We then compared PMTCT trends between 2010 and 2012 and 2013-2016 for the same four government hospitals. Results A total of 2,371 (91.1%) received some ART regimen, however; only 911 (56.2%) mothers received ART regimens compliant with WHO Option B+. From 2013 to 2016, the percent of mothers on WHO Option B + doubled from 42 to 84% (p < 0.001), the mean week of ART initiation decreased from 19.0 to 9.7 weeks (p < 0.001), the percent of pregnant women who were already on ART at the time of PMTCT enrolment increased from 5.8 to 31.7% (p < 0.001), and the paediatric transmission rate decreased from 5.9 to 2.5% (p = 0.002). Conclusion Comparing data at these four Kenyan hospitals indicates significant progress has been made from 2010 to 2016. To continue these positive gains, concerted focus will be needed to target and improve the integration of new guidelines into clinical practice at the facility level, adherence to treatment and retention in care.

Indexed as

Guidelines as TopicMothersAdultAnti-HIV AgentsChildFemaleFollow-Up StudiesGestational AgeGuideline AdherenceHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalKenyaOutcome Assessment, Health CarePregnancyAnti-HIV AgentsGestational week of initiationOption B+Pediatric HIV transmissionPreventing mother to child transmission (PMTCT)WHO guidelines

Identifiers

PMID30047080
PMCPMC6245141
OpenAlexW2883945186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.