Observational studyBiological trace element research2019
Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients.
Observational study in Biological trace element research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The Prognostic Value of Serum Zinc Levels in Acutely Hospitalized Patients: a Systematic Review.Biological trace element research · 2021Pooled it
- Effect of Multi-trace Elements Supplementation on Biochemical Markers and Postoperative Outcome in Patients Undergoing Elective Cardiac Surgery.Recent advances in inflammation & allergy drug discovery · 2025Trial
- Observational
- A Narrative Review of Metallomic Studies: Revealing the Toxic Metal Burden in Tobacco Smokers.International journal of molecular sciences · 2025Review
- Is the Concentration of Trace Elements Zinc, Selenium, Copper, Manganese, and Iron a Predictor of Clinical Outcomes in Critically Ill Trauma Patients?Biological trace element research · 2025Article
- Flame-Made Doped Iron Oxide Nanoparticles as Tracers for Magnetic Particle Imaging.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Study of plasma essential element concentrations to explore markers of acute myocardial infarction.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- What do we know about micronutrients in critically ill patients? A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025Review
- Article
- Thiamine use is associated with better outcomes for traumatic brain injury patients.Frontiers in nutrition · 2024Article
- Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge.Frontiers in physiology · 2024Review
- Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain.Journal of pain research · 2024Article
- The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis.Antioxidants (Basel, Switzerland) · 2023Review
- Comparison of micronutrients in adult enteral formulas widely used in clinical practice.Food science & nutrition · 2023Article
- Association Between the Ratios of Selenium to Several Elements and Mild Cognitive Impairment in the Elderly.Biological trace element research · 2023Article
- Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients.Nutrients · 2023Article
- Antioxidant and Immune-Related Implications of Minerals in COVID-19: A Possibility for Disease Prevention and Management.Antioxidants (Basel, Switzerland) · 2023Review
- The Independent Association of Plasma and Red Blood Cell Zinc Concentrations with Long-Term Outcomes of Hospitalized Patients.Current developments in nutrition · 2023Article
- Relationship between Plasma Levels of Zinc and Magnesium with the Treatment Process and Mortality Risk in COVID-19 Patients.Tanaffos · 2023Article
- The Extent of Burn Injury Significantly Affects Serum Micro- and Macroelement Concentrations in Patients on the First Day of Hospitalisation.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes of critically ill patients. A total of 167 participants (105 men and 62 women; average age, 61.4 years; age range, 18-90 years) were enrolled. Arterial blood concentrations of the trace elements zinc, copper, selenium, and manganese were measured every 14 days. At the time of intensive care unit (ICU) admission, serum concentrations of zinc, selenium, copper, and manganese were lower than the normal values in 75.1, 1.8, 37.8, and 2.1% of patients, respectively. Serum trace element concentrations measured on day 14 of ICU stay were higher than those measured at the time of ICU admission for zinc (53.3 → 80.7 μg/L) and copper (87.1 → 102.3 μg/L). Increased serum zinc and copper concentrations during ICU care were associated with a significantly lower mortality compared to decreased concentrations of zinc (15.6 vs. 83.3%, p = 0.003) and copper (5.6 vs. 50.0%, p = 0.013). At the time of ICU admission, low serum levels of zinc and copper were observed. Patients with increased serum concentrations of zinc and copper had significantly lower mortality.
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