Evidence map›Paper›PMID 30047012›Full record

ArticleHeart and vessels2019

Determination of the Th1, Th2, Th17, and Treg cytokine profile in patients with chronic Chagas heart disease and systemic arterial hypertension.

Reinaldo B Bestetti, Renata Dellalibera-Joviliano, Gabriel S Lopes, Milton Faria-Jr, Rosemary Furlan-Daniel, Kenio C Lopes, Divino R Batista

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Reinaldo B BestettiDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil. rbestetti44@gmail.com.
Renata Dellalibera-JovilianoDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil.
Gabriel S LopesDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil.
Milton Faria-JrDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil.
Rosemary Furlan-DanielDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil.
Kenio C LopesSão Rafael Clinic, Piumhi, Brazil.
Divino R BatistaDepartment of Medicine, UNAERP Medical School, University of Ribeirão Preto, Avenida Costábile Romano 2201, Ribeirão Prêto, 14096-900, Brazil.
Universidade de Ribeirão Preto · BRHospital São Rafael · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Chagas heart disease (CCHD affects about 30% of patients with chronic Chagas disease (CCD). Systemic arterial hypertension (SAH) afflicts about 25% of patients with CCD. The association of CCHD with SAH (CCHD-SAH) predisposes patients to develop chronic heart failure. The role of cytokines in disease progression in patients with CCHD-SAH is unknown. Accordingly, the aim of this study was to evaluate the plasma levels of cytokines expressing the Th1, Th2, Th17 pattern, as well as Treg cytokines, TNF-alpha, IL-1β, IL-8, IL-7 in patients with SAH-CCHD to get insight into the immunomodulation process in patients with this condition. Fifteen patients with CCHD, 22 patients with CCHD-SAH, and 28 controls were studied. All patients underwent history-taking, physical examination, 12-lead resting ECG, chest X-ray, and Doppler-echocardiogram. Ten of 15 (66%) patients with CCHD, and 16 of 22 (73%) patients with CCHD-SAH had decreased left ventricular ejection fraction (p > 0.05). Cytokines levels were performed on plasma samples using the ELISA method. Overall, proinflammatory, anti-inflammatory, and regulatory cytokine levels were increased in patients with CCHD-SAH in comparison to patients with CCHD and controls. However, such a difference was higher regarding IL-2, IL-5, IL-17, IL-12, and TNF-alpha cytokine levels, respectively. Cytokine levels were higher in CCHD patients in comparison to controls. Patients with CCHD-SAH have increased plasma levels of pro-inflammatory, anti-inflammatory, and regulatory cytokines in comparison with CCHD patients, thus suggesting a higher level of immunomodulation in patients with CCHD-SAH.

Indexed as

BiomarkersChagas CardiomyopathyChronic DiseaseCytokinesDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleHumansHypertensionMaleMiddle AgedTh17 CellsTh1 CellsTh2 CellsT-Lymphocytes, RegulatoryBiomarkersCytokinesChagas diseaseChronic heart diseaseChronic heart failureCytokines

Identifiers

PMID30047012
OpenAlexW2884174537

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.