Evidence map›Paper›PMID 30046988›Full record

ArticleAdvances in therapy2018

Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial.

Norbert J Tripolt, Slaven Stekovic, Felix Aberer, Jasmin Url, Peter N Pferschy, Sabrina Schröder, Nicolas Verheyen, Albrecht Schmidt, Ewald Kolesnik, Sophie H Narath and 5 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02673515 (The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02673515 nacompletednot on this map

The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy

TypeinterventionalSponsorMedical University of GrazRan2015 to 2019Enrolled60ConditionsExcessive Diet RestrictionArmsAlternate day fasting
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Is Water-Only Fasting Safe?Global advances in health and medicine · 2021
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Norbert J TripoltDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Slaven StekovicInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Felix AbererDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Jasmin UrlDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Peter N PferschyDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Sabrina SchröderInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Nicolas VerheyenDivision of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Albrecht SchmidtDivision of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Ewald KolesnikDivision of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Sophie H NarathCenter for Biomarker Research in Medicine, CBMed, Graz, Austria.
Regina RiedlInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Barbara Obermayer-PietschDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thomas R PieberDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Frank MadeoInstitute of Molecular Biosciences, University of Graz, Graz, Austria. frank.madeo@uni-graz.at.
Harald SourijDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. ha.sourij@medunigraz.at.
Medical University of Graz · ATCenter For Biomarker Research In Medicine · ATUniversity of Graz · AT

Funding

Austrian Science Fund FWF P 27893Austrian Science Fund FWF P 29203Austrian Science Fund FWF P 29262
6 · The paper itself

Abstract

BACKGROUND/

objectivesAlternate day fasting (ADF) is a subtype of intermittent fasting and is defined as a continuous sequence of a fast day (100% energy restriction, zero calories) and a feed day (ad libitum food consumption), resulting in roughly 36-h fasting periods. Previous studies demonstrated weight reductions and improvements of cardiovascular risk factors with ADF in obese subjects. However, rigorous data on potential endocrine, metabolic and cardiovascular effects, besides weight loss, are lacking. Therefore we aim to investigate the short- and mid- to long-term clinical and molecular effects of ADF in healthy non-obese subjects.

methodsWe will perform a prospective cohort study with an embedded randomized controlled trial (RCT) including 90 healthy subjects. Thirty of them will have performed ADF for at least 6 months (mid-term group). Sixty healthy subjects without a particular diet before enrolment will serve as the control group. These subjects will be 1:1 randomized to either continuing their current diet or performing ADF for 4 weeks. All subjects will undergo study procedures that will be repeated in RCT participants after 4 weeks. These procedures will include assessment of outcome parameters, dual-energy X-ray absorptiometry, measurement of endothelial function, an oral glucose tolerance test, 24-h blood pressure measurement, retinal vessel analysis, echocardiography and physical activity measurement by an accelerometer. Blood, sputum, buccal mucosa and faeces will be collected for laboratory analyses. Participants in the RCT will wear a continuous glucose monitor to verify adherence to the study intervention. PLANNED OUTCOMES: The aim of this project is to investigate the effects of ADF on human physiology and molecular cellular processes. This investigation should gain in-depth mechanistic insights into the concept of ADF and form the basis for larger subsequent cohort recruitment and consecutive intervention studies.

trial registrationNCT02673515; registered 24 November 2015. Current protocol date/version: 7 February 2017/version 1.8.

Indexed as

Caloric RestrictionFastingRandomized Controlled Trials as TopicAdultBlood GlucoseClinical ProtocolsCohort StudiesEnergy IntakeFemaleHumansHypertensionMaleObesityPilot ProjectsProspective StudiesBlood GlucoseAlternate day fastingBlood pressureCell deathCell signallingCohort studyEndothelial functionGlucose metabolismHealthy subjectsInsulin sensitivityIntermittent fasting

Identifiers

PMID30046988
PMCPMC6096974
OpenAlexW2884126215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.