Evidence map›Paper›PMID 30046962›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2019

Psychosocial Correlates of Monocyte Activation and HIV Persistence in Methamphetamine Users.

Kaitlin Grosgebauer, Jessica Salinas, Mark Sharkey, Margaret Roach, Suresh Pallikkuth, Samantha E Dilworth, Savita Pahwa, Tulay Koru-Sengul, Mario Stevenson, Adam W Carrico

Abstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Social Genomics of Methamphetamine Use, HIV Viral Load, and Social Adversity.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
    Article
  6. Article
  7. Post-traumatic Stress Disorder, Cocaine Use, and HIV Persistence.International journal of behavioral medicine · 2019
    Article
  8. Article
  9. Editor's Commentary for Special Issue: "The Role of Macrophages in HIV Persistence".Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kaitlin GrosgebauerSchool of Medicine, University of Miami, Miami, FL, USA.
Jessica SalinasSchool of Medicine, University of Miami, Miami, FL, USA.
Mark SharkeySchool of Medicine, University of Miami, Miami, FL, USA.
Margaret RoachSchool of Medicine, University of Miami, Miami, FL, USA.
Suresh PallikkuthSchool of Medicine, University of Miami, Miami, FL, USA.
Samantha E DilworthSchool of Medicine, University of California, San Francisco, CA, USA.
Savita PahwaSchool of Medicine, University of Miami, Miami, FL, USA.
Tulay Koru-SengulSchool of Medicine, University of Miami, Miami, FL, USA.
Mario StevensonSchool of Medicine, University of Miami, Miami, FL, USA.
Adam W CarricoSchool of Medicine, University of Miami, Miami, FL, USA. a.carrico@miami.edu.ORCID 0000-0002-8146-5701
University of Miami · USUniversity of California, San Francisco · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8M
RCT of an integrative intervention for non-treatment-seeking meth usersR01DA033854 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARRICO, ADAM WAYNE, MOSKOWITZ, JUDITH T. · 2013 to 2017
$2.8M
NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI073961NIDA NIH HHS R01 DA033854
6 · The paper itself

Abstract

This cross-sectional study investigated the associations of psychosocial factors relevant to recovery from substance use disorders with monocyte activation and HIV persistence in a sample of 84 HIV-positive, methamphetamine-using sexual minority men with undetectable HIV viral load (<40 copies/mL). We examined if psychosocial factors were associated with decreased soluble CD14 (sCD14) and lower proviral HIV DNA. Multiple linear regression models adjusted for age, anti-retroviral therapy regimen, and CD4+ T-cell count. Time on ART was also included in models examining proviral HIV DNA. Greater self-efficacy for managing methamphetamine triggers and higher social support for abstinence were independently associated with lower sCD14. Greater social support for abstinence was also independently associated with lower proviral HIV DNA. Psychosocial factors relevant to recovery from substance use disorders are associated with lower monocyte activation and decreased proviral HIV DNA. Findings underscore the need for longitudinal research to identify plausible mechanisms linking psychosocial factors and substance use with biological processes relevant to HIV pathogenesis.

Indexed as

AdultAmphetamine-Related DisordersCentral Nervous System StimulantsCross-Sectional StudiesDisease ProgressionHIV-1HIV InfectionsHumansLipopolysaccharide ReceptorsMaleMethamphetamineMiddle AgedMonocytesPsychologyViral LoadVirus LatencyCD14 protein, humanCentral Nervous System StimulantsLipopolysaccharide ReceptorsMethamphetamineHIV persistenceImmune activationMethamphetamineSelf-efficacySocial support

Identifiers

PMID30046962
PMCPMC6347547
OpenAlexW2884303003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.