Evidence map›Paper›PMID 30046950›Full record

ArticleSurgical endoscopy2019

Regression of intestinal metaplasia following magnetic sphincter augmentation device placement.

Evan T Alicuben, James M Tatum, Nikolai Bildzukewicz, Kamran Samakar, Jamil S Samaan, Einav N Silverstein, Kulmeet Sandhu, Caitlin C Houghton, John C Lipham

Abstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Magnetic sphincter augmentation: considerations for use in Barrett's esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023
    Article
  3. Article
  4. Magnetic challenge against gastroesophageal reflux.World journal of gastroenterology · 2021
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Evan T AlicubenDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
James M TatumDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Nikolai BildzukewiczDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Kamran SamakarDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Jamil S SamaanDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Einav N SilversteinDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Kulmeet SandhuDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
Caitlin C HoughtonDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.
John C LiphamDepartment of Surgery, Division of Upper GI and General Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA. john.lipham@med.usc.edu.
University of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal metaplasia represents an esophageal mucosal transformation due to uncontrolled gastroesophageal reflux disease. Fundoplication has been shown to lead to regression of disease. Magnetic sphincter augmentation is an alternative to fundoplication that effectively treats reflux disease. Initially, patients with intestinal metaplasia were not considered candidates for device placement, so outcomes in these patients are unknown.

methodsA retrospective review of all patients who underwent magnetic sphincter augmentation device placement between 2007 and 2017 was performed. All patients underwent pre-operative endoscopic evaluation and were categorized as having ultra-short segment (less than 1 cm), short-segment (1-3 cm), or long-segment (greater than or equal to 3 cm) disease. To be included in the study, pathologic examination demonstrating columnar mucosa with goblet cells was required.

resultsThere were 86 patients with biopsy-proven non-dysplastic intestinal metaplasia. 35 patients had ultra-short segment, 37 patients had short-segment, and 14 patients had long-segment disease. At a median follow-up of 1.2 years, 67/86 (78%) patients completed endoscopic follow-up. 48/67 (71.6%) patients had regression of intestinal metaplasia. There was no progression to dysplasia or carcinoma. Patients with abnormal post-operative DeMeester scores were less likely to have regression of disease. Regression was more likely in the ultra-short segment (82.8%) and short-segment (73.3%) groups compared to the long-segment group (25.0%).

conclusionsMagnetic sphincter augmentation is effective in achieving regression of intestinal metaplasia. Longer-term follow-up is needed to assess durability of effect and make meaningful comparisons to fundoplication.

Indexed as

MagnetsAdolescentAdultAgedAged, 80 and overBarrett EsophagusBiopsyEsophageal Sphincter, LowerEsophagusFemaleFundoplicationGastroesophageal RefluxHumansMagnetic PhenomenaMaleMiddle AgedBarrett’s esophagusGastroesophageal reflux diseaseIntestinal metaplasiaMagnetic sphincter augmentation

Identifiers

PMID30046950
OpenAlexW2883609290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.