Evidence map›Paper›PMID 30046944›Full record

ArticleEJNMMI research2018

[

Ephraim E Parent, Marc Benayoun, Ijeoma Ibeanu, Jeffrey J Olson, Constantinos G Hadjipanayis, Daniel J Brat, Vikram Adhikarla, Jonathon Nye, David M Schuster, Mark M Goodman

3 registry-linked trialsAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05553041 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of 18F-Fluciclovine PET-MRI to Differentiate Tumor Progression From Post-treatment Changes in Pediatric High-grade Glioma (HGG)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2024 to 2027Enrolled30ConditionsGlioma, High Grade Glioma, Glioma, Malignant, Glioma IntracranialArms18F-Fluciclovine PET-MRI
NCT05554302 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

TypeinterventionalSponsorBaptist Health South FloridaRan2023 to 2030Enrolled20ConditionsBrain Metastases, Brain CancerArms18F-Fluciclovine
NCT05555550 early_phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of 18F-Fluciclovine PET-MRI as a Biomarker of Response in Pediatric and Young Adult Patients With Low Grade Gliomas (LGG)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2026 to 2027Enrolled30ConditionsGlioma, Low-grade Glioma, Low Grade Glioma of Brain, Glioma, MalignantArms18F-Fluciclovine
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Clinical Practice Guidelines forAnnals of nuclear medicine · 2025
    Guideline
  2. Pooled it
  3. [European journal of nuclear medicine and molecular imaging · 2020
    Guideline
  4. Article
  5. Surgical neurology international · 2026
    Article
  6. CD98 Light Chain LAT1 Tracers in PET-CT Diagnosis of Cancer Patients.Anti-cancer agents in medicinal chemistry · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Impact of [Annals of nuclear medicine · 2024
    Article
  12. Review
  13. Diagnostic accuracy of anti-3-[European journal of nuclear medicine and molecular imaging · 2024
    Article
  14. Diagnostic Accuracy of PET withDiagnostics (Basel, Switzerland) · 2023
    Review
  15. Feasibility of [European journal of nuclear medicine and molecular imaging · 2023
    Article
  16. Journal of neuro-oncology · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ephraim E ParentDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1841 Clifton Rd. NE, 2nd floor, Atlanta, GA, 30329, USA.
Marc BenayounDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Ijeoma IbeanuDepartment of Radiology, Texas Tech University Health Sciences Center Foster School of Medicine, El Paso, TX, USA.
Jeffrey J OlsonDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Constantinos G HadjipanayisDepartment of Neurosurgery, Mount Sinai Beth Israel, New York, NY, USA.
Daniel J BratDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Vikram AdhikarlaDepartment of Information Sciences, City of Hope National Medical Center, Duarte, CA, USA.
Jonathon NyeDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1841 Clifton Rd. NE, 2nd floor, Atlanta, GA, 30329, USA.
David M SchusterDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1841 Clifton Rd. NE, 2nd floor, Atlanta, GA, 30329, USA.
Mark M GoodmanDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1841 Clifton Rd. NE, 2nd floor, Atlanta, GA, 30329, USA. mgoodma@emory.edu.

Funding

Leucine Type Amino Acid Transport In GliomasR01CA121320 · NCI · EMORY UNIVERSITY · PI GOODMAN, MARK MYRON · 2007 to 2012
$2.4M
National Institutes of Health R01 5RO1CA121320NCI NIH HHS R01 CA121320
6 · The paper itself

Abstract

backgroundThe ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of fluciclovine (

resultsSixteen patients with a total of 18 newly diagnosed low-grade gliomas (n = 6) and high grade gliomas (n = 12) underwent fluciclovine PET imaging after histopathologic assessment. Fluciclovine PET analysis comprised tumor SUV

conclusionsFluciclovine PET produces high-contrast images between both low-grade and high grade gliomas and normal brain by visual and semiquantitative analysis. Fluciclovine PET appears to discriminate between low-grade glioma and high-grade glioma, but must be validated with a larger sample size.

Indexed as

18F-fluciclovineAmino acidGliomaPET

Identifiers

PMID30046944
PMCPMC6060188

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.