Trial reportEuropean journal of nutrition2019
Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics.
Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02427555 (Effects of Barley Based Food Products on Metabolism and Gut Microflora), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Barley Based Food Products on Metabolism and Gut Microflora
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Effect of Barley and Oat Consumption on Immune System, Inflammation and Gut Microbiota: A Systematic Review of Randomized Controlled Trials.Current nutrition reports · 2024Pooled it
- A metabolome and microbiome wide association study of healthy eating index points to the mechanisms linking dietary pattern and metabolic status.European journal of nutrition · 2021Pooled it
- Dietary Fiber, Gut Microbiota, and Metabolic Regulation-Current Status in Human Randomized Trials.Nutrients · 2020Pooled it
- Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial.Gut microbes · 2023Trial
- Elucidating the role of the gut microbiota in the physiological effects of dietary fiber.Microbiome · 2022Trial
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance.European journal of clinical nutrition · 2020Trial
- Natural and Biological Products Therapeutic Potential in Restoring Gut Microbiome: Mechanistic Insights and Clinical Implications.Probiotics and antimicrobial proteins · 2026Review
- Gut Microbial Composition, Oxidative Stress, and Immunity in Metabolic Disease: Toward Personalized Interventions.Antioxidants (Basel, Switzerland) · 2026Review
- Metabolic Phenotypes, Genotypes, and Gut Microbiome Signatures in Obesity: Implications for Precision Nutrition Strategies in Type 2 Diabetes Prevention.Nutrition reviews · 2026Review
- In vitro fermentation characteristics of dietary fibers using fecal inocula from dogs treated with metronidazole.Animal microbiome · 2025Article
- Cross-population tongue image features and tongue coating microbiome changes in the evolution of colorectal cancer.Frontiers in microbiology · 2025Article
- The Impact of Prevotella on Neurobiology in Aging: Deciphering Dendritic Cell Activity and Inflammatory Dynamics.Molecular neurobiology · 2024Review
- Article
- Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity.Genome medicine · 2024Article
- Gut microbes differ in postmenopausal women responding to prunes to maintain hip bone mineral density.Frontiers in nutrition · 2024Article
- A flexible high-throughput cultivation protocol to assess the response of individuals' gut microbiota to diet-, drug-, and host-related factors.ISME communications · 2024Article
- Effects of whole-grain cereals on fecal microbiota and short-chain fatty acids in dogs: a comparison of rye, oats and wheat.Scientific reports · 2023Article
- Machine learning framework for gut microbiome biomarkers discovery and modulation analysis in large-scale obese population.BMC genomics · 2022Article
- Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health.Nutrients · 2022Review
- Effects of Two Kinds of Extracts ofFoods (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe previously showed that short-term intervention with barley kernel bread (BKB) improved glucose tolerance. However, glucose tolerance was not improved in a subset of individuals (non-responders) who were characterized by a low Prevotella/Bacteroides ratio. The purpose of the present study was to investigate if the baseline Prevotella/Bacteroides ratio can be used to stratify metabolic responders and non-responders to barley dietary fiber (DF).
methodsFecal samples were collected from 99 healthy humans with BMI < 28 kg/m
resultsThe BKB intervention lowered the blood glucose responses to the breakfast independently of Prevotella/Bacteroides ratios (P < 0.01). However, independently of intervention, the HP group displayed an overall lower insulin response and lower IL-6 concentrations compared with the LP group (P < 0.05). Furthermore, the groups HP and HPB showed lower hunger sensations compared to the LP group (P < 0.05).
conclusionsHere we show that the abundance of gut Prevotella and Bacteroides at baseline did not stratify metabolic responders and non-responders to barley DF intervention. However, our results indicate the importance of gut microbiota in host metabolic regulation, further suggesting that higher Prevotella/Bacteroides ratio may be favorable. CLINICALTRIALS. GOV ID: NCT02427555.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.