ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2018
Oxygen consumption during hypothermic and subnormothermic machine perfusions of porcine liver grafts after cardiac death.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Optimizing Temperature in Ex Situ Heart Perfusion: A Comparative Review of Traditional and Novel Methods in Heart Transplantation.Journal of cardiovascular development and disease · 2026Review
- Research progress on hepatic machine perfusion.International journal of medical sciences · 2021Review
- Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020Article
- Applicability of Hypothermic Oxygenate Machine Perfusion Preservation for Split-Liver Transplantation in a Porcine Model: An Experimental Study.Annals of transplantation · 2020Article
- Article
- Optimizing organs for transplantation; advancements in perfusion and preservation methods.Transplantation reviews (Orlando, Fla.) · 2020Review
- Individual and Combined Impact of Oxygen and Oxygen Transporter Supplementation during Kidney Machine Preservation in a Porcine Preclinical Kidney Transplantation Model.International journal of molecular sciences · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The use of grafts donated after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. Machine perfusion (MP) is a promising technology to improve DCD liver grafts. Several perfusion technologies under various temperature and oxygenation conditions have been suggested and are still debated. It is important to confirm the relationship between oxygen consumption and organ conditions during MP. In this study, we analyzed oxygen consumption during oxygenated MP of porcine DCD liver grafts under different temperature conditions: hypothermic and subnormothermic. Grafts exposed to 60 min of warm ischemia were perfused for 4 h with a modified UW-gluconate perfusate under hypothermic (HMP) and subnormothermic conditions. Oxygen consumption, pressures of the portal vein and hepatic artery, and effluent enzymes were analyzed. Oxygen consumption was strongly related to the graft temperature during MP. Effluent enzyme level of the LDH were lower in the high oxygen consumption group than in the low oxygen consumption group during MP. In summary, we found that high oxygen consumption under subnormothermic temperature conditions has several advantages over HMP for DCD liver graft preservation.
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