Observational studyThe journal of headache and pain2018
Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m.
Observational study in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Carnosic acid alleviates high-altitude cerebral edema by suppressing oxidative stress and microglia activation-induced neuroinflammation.Frontiers in pharmacology · 2026Article
- HRV and blood parameters for assessing the physiological functioning of cyclists during long-distance rides across different altitudes.Frontiers in physiology · 2025Article
- Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach.Physiological reports · 2024Article
- Machine learning-based prediction model for myocardial ischemia under high altitude exposure: a cohort study.Scientific reports · 2024Article
- Relationship between sociodemographic, clinical, and laboratory characteristics and severity of COVID-19 in pediatric patients.PloS one · 2024Article
- Article
- Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications.Frontiers in physiology · 2024Review
- The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure.National science review · 2023Article
- Positive Psychological Changes at High Altitude Shown by the Low Landers after the Yoga Intervention-Sudarshan Kriya Yoga (SKY).Annals of neurosciences · 2023Article
- Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude.Frontiers in pharmacology · 2023Article
- Intermittent hypoxic conditioning restores neurological dysfunction of mice induced by long-term hypoxia.CNS neuroscience & therapeutics · 2023Article
- Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache.Frontiers in physiology · 2022Article
- Article
- Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort.Phenomics (Cham, Switzerland) · 2021Article
- Sherpas, Coca Leaves, and Planes: High Altitude and Airplane Headache Review with a Case of Post-LASIK Myopic Shift.Current neurology and neuroscience reports · 2019Review
- Male reproductive system and simulated high-altitude environment: preliminary results in rats.Asian journal of andrologyArticle
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundHigh-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, hematological and biochemical risk factors associated with high-altitude headache (HAH) after acute exposure to 3700 m, we conducted a two-stage, perspective observational study. In 72 h, total 318 young Han Chinese males ascended from sea level (altitude of 50 m) to altitude of 3700 m by train. Demographic data, physiological, hematological and biochemical parameters of all participants were collected within one week prior to the departure, and within 24 h after arrival.
resultsThe incidence of HAH was 74.84%. For parameters measured at sea level, participants with HAH exhibited significantly higher age and lower BUN (p < 0.05). For parameters measured at 3700 m, participants with HAH exhibited significantly lower blood oxygen saturation (SpO
conclusionWe confirmed that higher HR, lower SpO
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