Evidence map›Paper›PMID 30046789›Full record

ArticleChemical communications (Cambridge, England)2018

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin.

Julian D Hegemann, Christopher J Schwalen, Douglas A Mitchell, Wilfred A van der Donk

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  2. Applied and environmental microbiology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Generation of Lasso Peptide-Based ClpP Binders.International journal of molecular sciences · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. How to harness biosynthetic gene clusters of lasso peptides.Journal of industrial microbiology & biotechnology · 2020
    Review
  16. Review
  17. Lasso Peptides: Heterologous Production and Potential Medical Application.Frontiers in bioengineering and biotechnology · 2020
    Review
  18. Article
  19. Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julian D HegemannHoward Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. vddonk@illinois.edu and Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. douglasm@illinois.edu.ORCID http://orcid.org/0000-0002-3859-8744
Christopher J SchwalenDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. douglasm@illinois.edu and Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA.
Douglas A MitchellDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. douglasm@illinois.edu and Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA.ORCID http://orcid.org/0000-0002-9564-0953
Wilfred A van der DonkHoward Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. vddonk@illinois.edu and Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, Illinois 61801, USA. douglasm@illinois.edu and Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA.ORCID http://orcid.org/0000-0002-5467-7071

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Training Program at the Chemistry Biology InterfaceT32GM136629 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Paul Hergenrother · 2020 to 2026
$4.5M
4800 Plus MALDI TOF/TOF AnalyzerS10RR027109 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2010 to 2010
$395k
NCRR NIH HHS S10 RR027109NIGMS NIH HHS T32 GM070421NIGMS NIH HHS T32 GM136629
6 · The paper itself

Abstract

Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate which residues are important for substrate recognition, proteolysis, and lasso peptide macrocyclization.

Indexed as

Amino Acid SubstitutionBacterial ProteinsModels, ChemicalPaenibacillusPeptide BiosynthesisPeptidesProtein Processing, Post-TranslationalBacterial ProteinsPeptides

Identifiers

PMID30046789
PMCPMC6092944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.