ArticleResearch and practice in thrombosis and haemostasis2018
Fibrinogen concentrations predict long-term cognitive outcome in young ischemic stroke patients.
Article in Research and practice in thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Cognitive impairment after a stroke in young adults: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- Cerebral Neurodegeneration and Cognitive Impairment in Patients on Maintenance Hemodialysis: the Role of Neuroglia and Associated Factors (Review).Sovremennye tekhnologii v meditsine · 2026Review
- Processing Speed and Attentional Shift/Mental Flexibility in Patients with Stroke: A Comprehensive Review on the Trail Making Test in Stroke Studies.Neurology international · 2024Review
- Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia.Frontiers in stroke · 2024Review
- Coagulation biomarkers for ischemic stroke.Research and practice in thrombosis and haemostasis · 2023Article
- Genetic influence on brain volume alterations related to self-reported childhood abuse.Frontiers in neuroscience · 2022Article
- Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients.Aging and disease · 2021Article
- Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.Thrombosis and haemostasis · 2021Article
- Article
- Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment.Dementia and geriatric cognitive disorders · 2020Article
- Fibrin(ogen) in human disease: both friend and foe.Haematologica · 2020Review
- Fibrinogen concentrations predict long-term cognitive outcome in young ischemic stroke patients.Research and practice in thrombosis and haemostasis · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is frequent after stroke, and young patients may live with this consequence for a long time. Predictors of cognitive outcomes after stroke represent a current gap of knowledge.
objectivesTo investigate levels of three hemostatic biomarkers as predictors of long-term cognitive function after stroke.
methodsThis longitudinal study included consecutively recruited patients with ischemic stroke at 18-69 years (n = 268). Blood was collected 3 months after index stroke and analyzed for plasma concentrations of fibrinogen, von Willebrand factor (VWF) and tissue-type plasminogen activator (t-PA) antigen. Cognitive function 7 years after index stroke was assessed by the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS). Participants with stroke <50 years of age were also examined by the Trail Making Test A and B (n = 41). Associations between biomarker concentrations and cognitive scales were assessed in the whole group and in participants with stroke <50 years of age.
resultsThe hemostatic biomarkers fibrinogen, VWF and t-PA, were all correlated to total BNIS score, but these associations did not withstand adjustment for confounding factors in the whole group. However, in patients <50 years, we found an independent association between fibrinogen concentrations and total BNIS score (β
conclusionHigh convalescent fibrinogen concentrations were associated with worse long-term cognitive outcomes in ischemic stroke <50 years of age. We propose further investigations of fibrinogen in relation to cognitive function in stroke in the young.
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