ArticleResearch and practice in thrombosis and haemostasis2018
Characteristics of pain, other symptoms and function in pediatric post-thrombotic syndrome.
Article in Research and practice in thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Clinical care of pediatric patients with or at risk of postthrombotic syndrome: guidance from the ISTH SSC Subcommittee on pediatric and neonatal thrombosis and hemostasis.Journal of thrombosis and haemostasis : JTH · 2024Guideline
- Skeletal muscle oxygenation and fluid content in upper extremity postthrombotic syndrome: a proof-of-concept study.Research and practice in thrombosis and haemostasis · 2025Article
- Unraveling the pathophysiology of lower-limb postthrombotic syndrome in adolescents: a proof-of-concept study.Blood advances · 2023Article
- Review
- Impact of deep vein thrombosis on adolescent athletes: Navigating an invisible disability.Research and practice in thrombosis and haemostasis · 2022Article
- Characteristics of pain, other symptoms and function in pediatric post-thrombotic syndrome.Research and practice in thrombosis and haemostasis · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
essentials
backgroundSymptoms and function in pediatric post-thrombotic syndrome (PTS) remain poorly characterized.
methodsThe present cross-sectional study describes the characteristics of pain, other symptoms, and impaired function in pediatric PTS in a cohort of children with history of upper or lower limb deep vein thrombosis and PTS diagnosis. The frequency of clinical findings was compared between patients with and without pain, and between patients with upper and lower extremity PTS.
resultsSeventy-eight children were included in the study. The most common PTS symptoms were pain, tired limb and heaviness. Symptoms were usually reported to occur at mid-day or later and were typically triggered by exercise. Half the patients reported impaired endurance. Pain was reported by 45% of patients and was usually mild-moderate. Heaviness, tightness, tired limb, paresthesia, self-reported limb edema, and impaired endurance were most common in patients with than in patients without pain. Conversely, activity and participation scores, skin redness, and clinician-assessed limb edema did not differ between patients with and without pain. Lastly, there was no difference in pain intensity or frequency of paresthesia, swelling, heaviness, or impaired endurance when comparing the upper and lower extremities.
conclusionTired limb, heaviness, pain, and impaired endurance were the most frequent clinical findings in pediatric PTS. Frequency of symptoms and pain intensity did not differ between upper and lower extremities. Pain was associated with the presence of other symptoms and impaired function, but not with activity limitation and participation restriction. Better tools are needed to measure these two latter aspects of health.
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