ArticleResearch and practice in thrombosis and haemostasis2018
The association between red cell distribution width and venous thromboembolism is not explained by myocardial infarction, stroke, or cancer.
Article in Research and practice in thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Mechanobiology of cancer-associated thrombosis: from molecular mechanisms to therapeutic innovation.Journal of nanobiotechnology · 2026Review
- Correlation between red blood cell distribution width and deep vein thrombosis in patients with lower limb fractures.Frontiers in cardiovascular medicine · 2026Article
- Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review.Annals of translational medicine · 2020Article
- "Trending" statistical methods.Research and practice in thrombosis and haemostasis · 2018Article
- The association between red cell distribution width and venous thromboembolism is not explained by myocardial infarction, stroke, or cancer.Research and practice in thrombosis and haemostasis · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRed cell distribution width (RDW) is a risk marker of venous thromboembolism (VTE), myocardial infarction (MI), stroke, and cancer. Due to interrelations between these diseases, the association between RDW and VTE may be explained by MI, stroke, or cancer.
objectiveTo investigate whether the effect of RDW on VTE could be explained by intermediate development of MI, stroke, or cancer.
methodsRDW was measured in 24 363 participants of the Tromsø Study in 1994-1995. Incident VTE, MI, stroke, and cancer were registered until December 31, 2010. Conventional and cause-specific Cox-regression models were used to estimate hazard ratios (HR) for VTE with 95% confidence intervals (CI) across categories of RDW.
resultsThere were 502 first VTEs during a median follow-up of 16 years. In conventional Cox regression analysis, RDW in the highest quartile was associated with a 71% (HR 1.71, 95% CI 1.09-2.67) and 27% (HR 1.27, 95% CI 0.88-1.85) higher risk of VTE in men and women, respectively, compared to subjects in the lowest quartiles. The risk of VTE among subjects with RDW in the highest quartile was similar for men and women of postmenopausal age. In cause-specific analysis, where each individual contributed with person-time until the first occurring event only, the risk estimates were similar to those of the conventional Cox-regression analysis.
conclusionOur findings suggest that the association between RDW and future risk of VTE is not explained by intermediate development of MI, stroke, or cancer.
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