ArticleResearch and practice in thrombosis and haemostasis2018
Acute infection as a trigger for incident venous thromboembolism: Results from a population-based case-crossover study.
Article in Research and practice in thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Magnitudes of Risk Factors of Venous Thromboembolism and Quality of Anticoagulant Therapy in Ethiopia: A Systematic Review.Vascular health and risk management · 2022Pooled it
- Risk of Venous Thromboembolism in Infectious Diseases: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Joint effects of atrial fibrillation and prothrombotic genotypes on the risk of venous thromboembolism.Research and practice in thrombosis and haemostasis · 2025Article
- Dispensed prescription medications and short-term risk of pulmonary embolism in Norway and Sweden.Scientific reports · 2024Article
- Postoperative venous thromboembolism risk in patients with vulvar carcinoma: An analysis of the National surgical Quality Improvement Program (NSQIP) database.Gynecologic oncology reports · 2024Article
- Sex-specific differences in the clinical profile among psychiatric patients with pulmonary Embolism: a hospital-based retrospective study.BMC pulmonary medicine · 2024Article
- Development and validation of a nomogram model for central venous access device-related thrombosis in hospitalized children.European journal of pediatrics · 2023Article
- Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism.JACC. Basic to translational science · 2023Review
- Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study.TH open : companion journal to thrombosis and haemostasis · 2023Article
- Pulmonary embolism at CT pulmonary angiography in patients with COVID-19 at a tertiary care center in Nepal: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Association between age and incidence of deep vein thrombosis in patients with spinal cord injury: an observational cross-sectional study.Spinal cord · 2022Observational
- Predictors of venous thromboembolism in COVID-19 patients: results of the COVID-19 Brazilian Registry.Internal and emergency medicine · 2022Article
- Venous thromboembolism in critically ill patients with pneumonia in the pre-COVID-19 era: Data from a large public database.Research and practice in thrombosis and haemostasis · 2022Article
- Postoperative venous thromboembolism event increases risk of readmissions and reoperation following total joint arthroplasty: a propensity-matched cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Increased Association of Pulmonary Thromboembolism and Tuberculosis during COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital.Antibiotics (Basel, Switzerland) · 2022Article
- Hypercoagulation in COPD: the clot thickens.ERJ open research · 2021Article
- Risk Factors for Catheter-Related Thrombosis in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.Medicina (Kaunas, Lithuania) · 2021Article
- Hemostatic parameters in patients with spinal cord injury in subacute and chronic phase of the rehabilitation.The journal of spinal cord medicine · 2021Article
- Ischemic Stroke: An Underestimated Complication of COVID-19.Aging and disease · 2021Article
- SARS-CoV-2 Infection: Modulator of Pulmonary Embolism Paradigm.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE-risk is explained by immobilization is unknown.
aimsTo investigate the impact of hospitalization with acute infection on the VTE-risk in patients with and without concomitant immobilization, and to explore the differential impact of respiratory- (RTI) and urinary- (UTI) tract infections on the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).
methodsWe conducted a case-crossover study of VTE-patients (n = 707) recruited from a general population. Hospitalizations and VTE-triggers were registered during the 90 days before a VTE (hazard period) and in four preceding 90-day control periods. Conditional logistic regression was used to estimate odds ratios (ORs) for VTE according to triggers.
resultsAcute infection was registered in 267 (37.8%) of the hazard periods and in 107 (3.8%) of the control periods, corresponding to a high VTE-risk after infection (OR 24.2, 95% CI 17.2-34.0), that was attenuated to 15-fold increased after adjustment for immobilization. The risk was 20-fold increased after infection without concomitant immobilization, 73-fold increased after immobilization without infection, and 141-fold increased with the two combined. The risk of PE was apparently higher after RTIs (OR 48.3, 95% CI 19.4-120.0) than UTIs (OR 12.6, 95% CI 6.4-24.7), but diminished in sensitivity analyses excluding uncertain RTI diagnoses.
conclusionsOur findings suggest that hospitalization with infection is a strong VTE-trigger also in non-immobilized patients. Infection and immobilization had a synergistic effect on the VTE-risk.
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