ArticleResearch and practice in thrombosis and haemostasis2017
Thromboelastography does not predict outcome in different etiologies of cirrhosis.
Article in Research and practice in thrombosis and haemostasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Viscoelastic testing: Transforming hemostasis management in patients in the medical intensive care unit.World journal of critical care medicine · 2026Review
- Beyond the INR: Thromboelastography Carries Prognostic Information in Critically Ill Patients With Cirrhosis.Canadian journal of gastroenterology & hepatology · 2026Article
- Histologic evidence of neutrophil extracellular traps and fibrin(ogen) deposition in liver biopsies from patients with inflammatory liver disease.Research and practice in thrombosis and haemostasis · 2025Article
- Does the Use of Viscoelastic Hemostatic Assays for Periprocedural Hemostasis Management in Liver Disease Improve Clinical Outcomes?Transfusion medicine reviews · 2024Review
- The Role of Viscoelastic Testing in Assessing Hemostasis: A Challenge to Standard Laboratory Assays?Journal of clinical medicine · 2024Review
- Hypocoagulability in severe yellow fever infection is associated with bleeding: results from a cohort study.Research and practice in thrombosis and haemostasis · 2024Article
- Fibrin clot properties and thrombus composition in cirrhosis.Research and practice in thrombosis and haemostasis · 2023Article
- Pathophysiology and management of bleeding and thrombosis in patients with liver disease.International journal of laboratory hematology · 2022Review
- Hemostasis testing in patients with liver dysfunction: Advantages and caveats.World journal of gastroenterology · 2021Review
- Viscoelastic tests in liver disease: where do we stand now?World journal of gastroenterology · 2021Review
- Reduced Clot Stability by Thromboelastography as a Potential Indicator of Procedure-Related Bleeding in Decompensated Cirrhosis.Hepatology communications · 2021Article
- Background and Evaluation of Hypercoagulability.Gastroenterology & hepatology · 2021Article
- Features of Blood Clotting on Thromboelastography in Hospitalized Patients With Cirrhosis.The American journal of medicine · 2020Article
- Primary Hemostasis in Chronic Liver Disease and Cirrhosis: What Did We Learn over the Past Decade?International journal of molecular sciences · 2020Review
- Whole blood thrombin generation profiles of patients with cirrhosis explored with a near patient assay.Journal of thrombosis and haemostasis : JTH · 2020Article
- Standard coagulation tests are superior to thromboelastometry in predicting outcome of patients with liver cirrhosis.PloS one · 2020Article
- Successful management of refractory bleeding in liver failure with tranexamic acid: Case report and literature review.Research and practice in thrombosis and haemostasis · 2019Article
- The Misunderstood Coagulopathy of Liver Disease: A Review for the Acute Setting.The western journal of emergency medicine · 2018Review
- Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference.Thrombosis and haemostasis · 2018Article
- Thromboelastography does not predict outcome in different etiologies of cirrhosis.Research and practice in thrombosis and haemostasis · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew laboratory tests that measure global hemostasis indicate generally preserved hemostatic function in patients with cirrhosis. It is not known whether normal hemostatic function is maintained across various subsets of patients.
objectivesIn the present study, we investigated clot generation and clot lysis kinetics in a large group of patients with different etiologies of disease. PATIENTS/
methodsBlood samples of 270 patients with cirrhosis were studied using thromboelastography (TEG), which measures the dynamic and physical properties of clot formation and lysis in whole blood. TEG parameters of different subsets of the patient population were compared. Correlations with routine laboratory tests as well as clinical outcomes were explored.
resultsOverall, TEG parameters were normal and similar between underlying disease etiologies. A proportion of subjects showed hypocoagulable features, with the exception of patients with cholestatic cirrhosis in whom TEG readings showed hypercoagulable features. In all groups, K-time, α-Angle, and MA correlated well with platelet counts and fibrinogen plasma levels. After a mean follow-up of 2 years and 11 months, 31 patients had experienced a bleeding event, 8 had developed thrombosis, and 173 patients (64%) had undergone liver transplantation and/or had died. TEG baseline parameters were similar between patients subdivided according to outcome.
conclusionsTEG parameters reflected generally preserved function of the hemostatic system in patients with cirrhosis, with hypo- and hypercoagulable features in subsets of patients with specific underlying disease etiologies. Abnormalities in TEG parameters did however not predict bleeding, thrombosis, or risk of liver transplantation and/or death.
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