Evidence map›Paper›PMID 30046664›Full record

ArticleCell surface (Amsterdam, Netherlands)2018

Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis.

Víctor M Hernández-Rocamora, Christian F Otten, Atanas Radkov, Jean-Pierre Simorre, Eefjan Breukink, Michael VanNieuwenhze, Waldemar Vollmer

Open access · hybridAbstract read
In one paragraph

Article in Cell surface (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
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  14. Regulation of peptidoglycan synthesis and remodelling.Nature reviews. Microbiology · 2020
    Review
  15. Overexpression ofMicroorganisms · 2020
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Víctor M Hernández-RocamoraCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.
Christian F OttenCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.
Atanas RadkovDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA.
Jean-Pierre SimorreInstitut de Biologie Structurale, Université Grenoble Alpes, Grenoble, France.
Eefjan BreukinkMembrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, University of Utrecht, Padualaan 8, 3584 Utrecht, The Netherlands.
Michael VanNieuwenhzeDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA.
Waldemar VollmerCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.
Newcastle University · GBIndiana University Bloomington · USInstitut de Biologie Structurale · FRUtrecht University · NL

Funding

Novel Inhibitors of Peptidoglycan Biosynthesis Targeting Gram-positive PathogensR01GM111537 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI VANNIEUWENHZE, MICHAEL S · 2014 to 2017
$1.4M
Medical Research Council MR/N501840/1NIGMS NIH HHS R01 GM111537Wellcome Trust
6 · The paper itself

Abstract

Peptidoglycan (PG) is an essential component of the bacterial cell wall that maintains the shape and integrity of the cell. The PG precursor lipid II is assembled at the inner leaflet of the cytoplasmic membrane, translocated to the periplasmic side, and polymerized to glycan chains by membrane anchored PG synthases, such as the class A Penicillin-binding proteins (PBPs). Polymerization of PG releases the diphosphate form of the carrier lipid, undecaprenyl pyrophosphate (C55-

Indexed as

BacAPBP1BPenicillin-binding proteinPeptidoglycanPgpBUndecaprenyl phosphate

Identifiers

PMID30046664
PMCPMC6053597
OpenAlexW2802985714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.