ArticleTransplantation direct2018
First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion.
Article in Transplantation direct, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- ECMO-Assisted In-Situ Normothermic Perfusion for Donation After Circulatory Determination of Death Kidney Transplantation: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Early and Mid-Term Results of Solid Organ Transplantation After Circulatory Death: A 4-Year Single Centre Experience.Medicina (Kaunas, Lithuania) · 2025Article
- Out-of-Hospital Cardiac Arrest Patients: Different Donor Pathways for an Existing Donor Pool Still Underestimated-Perspective.Journal of clinical medicine · 2025Article
- Solid organ transplantation originating from uncontrolled donation after circulatory death in Europe: a narrative review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Review
- Relatives' and Intensive Care Unit Personnel's Perspectives of Care in Organ Donation: Protocol for a Multiple Methods Study.JMIR research protocols · 2024Article
- Perfusion Techniques in Kidney Allograft Preservation to Reduce Ischemic Reperfusion Injury: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2024Review
- Benefits of Living Over Deceased Donor Kidney Transplantation in Elderly Recipients. A Propensity Score Matched Analysis of a Large European Registry Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2024Observational
- [Organ donation-Not only a responsibility of intensive care medicine].Der Anaesthesist · 2022Review
- Donation after circulatory death liver transplantation: consensus statements from the Spanish Liver Transplantation Society.Transplant international : official journal of the European Society for Organ Transplantation · 2020Article
- Kidney transplantation: an attractive and cost-effective alternative for older patients? A cost-utility study.Clinical kidney journal · 2019Article
- Organ donation after circulatory death: current status and future potential.Intensive care medicine · 2019Review
- Swedish Intensive Care Nurses' Knowledge, Attitudes, and Views on Donation After Circulatory Death Before a National Implementation.SAGE open nursingArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDonation after circulatory death (DCD) can increase the pool of available organs for transplantation. This pilot study evaluates the implementation of a controlled DCD (cDCD) protocol using normothermic regional perfusion in Norway.
methodsPatients aged 16 to 60 years that are in coma with documented devastating brain injury in need of mechanical ventilation, who would most likely attain cardiac arrest within 60 minutes after extubation, were eligible. With the acceptance from the next of kin and their wish for organ donation, life support was withdrawn and cardiac arrest observed. After a 5-minute no-touch period, extracorporeal membrane oxygenation for post mortem regional normothermic regional perfusion was established. Cerebral and cardiac reperfusion was prevented by an aortic occlusion catheter. Measured glomerular filtration rates 1 year postengraftment were compared between cDCD grafts and age-matched grafts donated after brain death (DBD).
resultsEight cDCD were performed from 2014 to 2015. Circulation ceased median 12 (range, 6-24) minutes after withdrawal of life-sustaining treatment. Fourteen kidneys and 2 livers were retrieved and subsequently transplanted. Functional warm ischemic time was 26 (20-51) minutes. Regional perfusion was applied for 97 minutes (54-106 minutes). Measured glomerular filtration rate 1 year postengraftment was not significantly different between cDCD and donation after brain death organs, 75 (65-76) vs 60 (37-112) mL/min per 1.73 m
conclusionA protocol for cDCD is successfully established in Norway. Excellent transplant outcomes have encouraged us to continue this work addressing the shortage of organs for transplantation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.