Evidence map›Paper›PMID 30046616›Full record

ReviewJournal of diabetes research2018

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications.

Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of diabetes research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Bou-Yue PengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Navneet Kumar DubeyCeramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Viraj Krishna MishraApplied Biotech Engineering Centre (ABEC), Department of Biotechnology, Ambala College of Engineering and Applied Research, Ambala, India.
Feng-Chou TsaiDepartment of Stem Cell Research, Cosmetic Clinic Group, Taipei City 110, Taiwan.
Rajni DubeyGraduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan.
Win-Ping DengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan.ORCID 0000-0003-2180-0472
Hong-Jian WeiStem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-5962-7831
Fu Jen Catholic University · TWNational Taiwan University · TWTaipei Medical University · TWTaipei Medical University Hospital · TWTon Duc Thang University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.

Indexed as

Stem Cell TransplantationAnimalsCell LineageDiabetes Mellitus, Type 2Diabetic AngiopathiesDiabetic CardiomyopathiesDiabetic RetinopathyHumansHyperglycemiaInsulinInsulin ResistanceMiceMicrocirculationNitrosative StressOxidative StressSignal TransductionInsulin

Identifiers

PMID30046616
PMCPMC6036791
OpenAlexW2809967957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.