ArticleBioMed research international2018
Association of Initial Serum Total Calcium Concentration with Mortality in Critical Illness.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Role of the ionized-to-total calcium ratio in predicting sepsis mortality: a retrospective analysis from the MIMIC-IV database.BMC infectious diseases · 2026Article
- Association between corrected serum calcium levels and 28-day mortality in patients with sepsis: A cohort study.Medicine · 2026Article
- Initial serum chloride is associated with all-cause mortality in critically ill patients with acute kidney injury.Renal failure · 2025Article
- Article
- Can Ionized Calcium Levels Differentiate Acute Anemia and Chronic Anemia in Patients Transfused in the Emergency Department?Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Magnesium disturbances in critically ill children.Scientific reports · 2025Observational
- Association between albumin-corrected calcium and all-cause mortality in patients with heart failure: a retrospective study.Frontiers in cardiovascular medicine · 2025Article
- Association between serum calcium levels and in-hospital mortality in sepsis: A retrospective cohort study.Heliyon · 2024Article
- Investigating Potential Correlations between Calcium Metabolism Biomarkers and Periprocedural Clinical Events in Major Cardiovascular Surgeries: An Exploratory Study.Journal of clinical medicine · 2024Article
- Impact of obesity on outcomes of patients with acute respiratory distress syndrome: a retrospective analysis of a large clinical database.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study.Journal of laboratory physicians · 2023Article
- Non-linear relationship between albumin-corrected calcium and 30-day in-hospital mortality in ICU patients: A multicenter retrospective cohort study.Frontiers in endocrinology · 2022Article
- Clinical Features and Factors Associated With Sepsis-Associated Encephalopathy in Children: Retrospective Single-Center Clinical Study.Frontiers in neurology · 2022Article
- Impact of obesity on outcomes in patients with acute respiratory syndrome.The Journal of international medical research · 2021Article
- The Prognostic Value of Calcium in Post-Cardiovascular Surgery Patients in the Intensive Care Unit.Frontiers in cardiovascular medicine · 2021Article
- Admission Serum Ionized and Total Calcium as New Predictors of Mortality in Patients with Cardiogenic Shock.BioMed research international · 2021Article
- Hypochloremia is associated with increased risk of all-cause mortality in patients in the coronary care unit: A cohort study.The Journal of international medical research · 2020Article
- Ringer's Lactate Prevents Early Organ Failure by Providing Extracellular Calcium.Journal of clinical medicine · 2020Article
- Relation between Red Cell Distribution Width and Mortality in Critically Ill Patients with Acute Respiratory Distress Syndrome.BioMed research international · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have suggested that serum ionized calcium (iCa) is associated with mortality in critical illness. However, evidence regarding the predictive significance of serum total calcium (tCa) in critical illness remains scarce. The aim of this study was to assess the association of tCa levels with mortality in critical illness.
methodsWe employed the MIMIC-III v1.3 database. tCa was measured upon ICU admission and its relationship with mortality was determined using smooth curve fitting. The association between admission tCa levels and hospital mortality was determined using logistic regression.
resultsInclusion criteria were met by 44,886 critically ill patients. A U-shaped pattern was observed between tCa and hospital mortality. Similar trends were observed for hospital mortality when quintiles were used to group patients according to tCa. In multivariate analysis, adjusted for age and sex, the model indicated that admission tCa levels ⩽7.6mg/dl, 7.7-8.1mg/dl, and
conclusionsThe relationship between tCa and hospital mortality followed a ''U" shaped curve. tCa had certain prognostic value in critically ill patients, but it had no independent association with hospital mortality.
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