ArticleInternational journal of ophthalmology2018
Triptolide inhibits TGF-β-induced matrix contraction and fibronectin production mediated by human Tenon fibroblasts.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- A Pilot Investigation of Transforming Growth Factor-β2 and Total Protein Concentrations in Aqueous Humor of Canine Glaucomatous Eyes With and Without Ahmed Glaucoma Valve Surgery.Veterinary ophthalmology · 2026Article
- Augmented Wound-Healing Effect of Sodium Thiosulfate-Infused Cosmetic Creams in Frostbite.Pharmaceutics · 2025Article
- 17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblastsInternational journal of ophthalmology · 2023Article
- Involvement of METTL3/mJournal of molecular histology · 2021Article
- Triptolide improves myocardial fibrosis in rats through inhibition of nuclear factor kappa B and NLR family pyrin domain containing 3 inflammasome pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- The control of conjunctival fibrosis as a paradigm for the prevention of ocular fibrosis-related blindness. "Fibrosis has many friends".Eye (London, England) · 2020Review
- Dasatinib inhibits peripapillary scleral myofibroblast differentiation.Experimental eye research · 2020Article
- The conjunctival transcriptome in Ethiopians after trichiasis surgery: associations with the development of eyelid contour abnormalities and the effect of oral doxycycline treatment.Wellcome open research · 2019Article
- Nintedanib inhibits TGF-β-induced myofibroblast transdifferentiation in human Tenon's fibroblasts.Molecular vision · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine if triptolide influences the contractility and fibronectin production in human Tenon fibroblasts (HTFs).
methodsHTFs were cultured in type I collagen gels with or without transforming growth factor beta (TGF-β) and/or triptolide. The diameter of the collagen gel was used to measure contraction. Immunoblot analysis was used to quantify myosin light chain (MLC) phosphorylation and integrin expression. Laser confocal fluorescence microscopy was used to monitor the formation of actin stress fibers. Fibronectin production was measured with an enzyme immunoassay.
resultsTriptolide inhibition of contraction in TGF-β-induced collagen gel mediated by HTFs was dose-dependent and statistically significant at 3 nmol/L (
conclusionTriptolide suppress the contractility of HTFs induced by TGF-β and the production of fibronectin by these cells. It is promising that triptolide treatment may possibly inhibit scar formation after glaucoma filtration surgery.
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Registered trials
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