ArticleInternational journal of ophthalmology2018
Screening of methylation genes in age-related cataract.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The role of DNMT3B, GSK-3β and GJA3 in lens epithelial cell apoptosis and age-related cataract.BMC ophthalmology · 2026Article
- Aging of the human eye lens: Epigenetic landscape and therapeutic targets in age‑related cataracts (Review).International journal of molecular medicine · 2025Review
- Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model.PloS one · 2025Article
- DNA hypermethylation ofInternational journal of ophthalmology · 2024Article
- Short-term smoking cessation leads to a universal decrease in whole blood genomic DNA methylation in patients with a smoking history.World journal of surgical oncology · 2023Article
- Aberrant expression ofInternational journal of ophthalmology · 2023Article
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Authors and funding
3 authors.
Funding
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Abstract
aimTo analyze and screen the methylation status of whole-genome in age-related cataract samples.
methodsAnterior lens capsule samples were collected from age-related cortical cataract patients over 50 years of age with LOCS III score of nuclear color ≥4 along with control subjects. DNAs were extracted and subjected to methylation microarray for the identification of methylated genes employing the high-throughput sequencing approach.
resultsCompared with the control group, 843 sites were found methylated, including 802 hypermethylation sites with 542 corresponding genes, 41 demethylation sites with 29 corresponding sites. COL4A1, GJA3, SIPA1L3 were confirmed by mass spectrometry, the results were consistent with high-throughput sequencing.
conclusionDNA methylation microarrays is an efficient way for screening the aberrantly methylated genes. In this study, we are able to screen a few age-related cataract genes such as COL4A1, GJA3, and SIPA1L3 for their aberrant methylation patterns in cataract patients however further work is warranted to understand the significance of these findings.
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