ArticleInternational journal of ophthalmology2018
Evaluation of a rat meibomian gland dysfunction model induced by closure of meibomian gland orifices.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Applied anatomy and morphology of Meibomian glands in the non-human primate.Scientific reports · 2025Article
- Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression.Scientific reports · 2024Article
- Alkali burn injury model of meibomian gland dysfunction in mice.International journal of ophthalmology · 2024Article
- Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway.Investigative ophthalmology & visual science · 2022Article
- Meibomian Gland Dysfunction: What Have Animal Models Taught Us?International journal of molecular sciences · 2020Review
- Meibomian gland dysfunction model induced with complete Freund's adjuvant in C57BL/6 mice.International journal of ophthalmology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo find a stable, inexpensive, and reliable method to produce a rat meibomian gland dysfunction (MGD) model.
methodsWe inserted slim guidewires into the meibomian gland orifices of twelve Brown Norway rats and fulgurized every guidewire to destroy part of the meibomian gland. We then observed the morphological changes in the eyelid margin, and compared the data of tear breakup time (TBUT), Schirmer I test, and the corneal fluorescence staining scores at different times (1, 2, 4, and 6wk). We observed pathological changes of the cornea, conjunctiva and meibomian gland, and we used real-time polymerase chain reaction to analyze epithelial growth factor (EGF), interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and Ki67.
resultsIn the fourth week, compared with the control group, the TBUT of the model group began to decreased (
conclusionThe MGD rat model, produced
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Registered trials
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