Evidence map›Paper›PMID 30046482›Full record

ReviewJournal of advanced research2018

A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives.

Mahmuda Akter, Md Tajuddin Sikder, Md Mostafizur Rahman, A K M Atique Ullah, Kaniz Fatima Binte Hossain, Subrata Banik, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 394 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Review
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  11. Green Synthesis Characterization and Evaluation ofMolecules (Basel, Switzerland) · 2026
    Article
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  14. Harnessing the Antimicrobial Potential of Baicalein-Coated FeACS applied materials & interfaces · 2026
    Article
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  18. Review
  19. Article
  20. Advances in the application of molecular docking in nanomedicine.Journal of computer-aided molecular design · 2026
    Article

334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahmuda AkterGraduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan.
Md Tajuddin SikderGroup of Environmental Adaptation Science, Faculty of Environmental Earth Science, Hokkaido University, Kita 10, Nishi 5, Kita-ku, 060-0810 Sapporo, Japan.
Md Mostafizur RahmanGraduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan.
A K M Atique UllahChemistry Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission, Dhaka 1000, Bangladesh.
Kaniz Fatima Binte HossainGraduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan.
Subrata BanikGraduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan.
Toshiyuki HosokawaResearch Division of Higher Education, Institute for the Advancement of Higher Education, Hokkaido University, Sapporo 060-0817, Japan.
Takeshi SaitoFaculty of Health Sciences, Hokkaido University, Sapporo 060-0817, Japan.
Masaaki KurasakiGraduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one of the most in-demand nanoparticles owing to their exponential number of uses in various sectors. The increased use of Ag-NPs-enhanced products may result in an increased level of toxicity affecting both the environment and living organisms. Several studies have used different model cell lines to exhibit the cytotoxicity of Ag-NPs, and their underlying molecular mechanisms. This review aimed to elucidate different properties of Ag-NPs that are responsible for the induction of cellular toxicity along with the critical mechanism of action and subsequent defense mechanisms observed

Indexed as

Ag-NPs, silver nanoparticlesAg+, silver ionsCytotoxicityDNA, deoxyribonucleic acidGSH, glutathioneLDH, lactate dehydrogenaseMechanismNPs, nanoparticlesPhysiochemical propertiesppm, parts per millionPVP, polyvinylpyrrolidoneROS, reactive oxygen speciesSilver nanoparticlesTMRE, tetramethylrhodamine ethyl esterTT, toxicity threshold

Identifiers

PMID30046482
PMCPMC6057238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.