Evidence map›Paper›PMID 30046328›Full record

ArticleElectrolyte & blood pressure : E & BP2018

The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II.

Jae Hwi Sung, Ahran Song, Taegun Park, Eunyoung Kim, Seunggwan Lee

Open access · diamondAbstract read
In one paragraph

Article in Electrolyte & blood pressure : E & BP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.International journal of biological sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jae Hwi SungIntegrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.
Ahran SongIntegrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.
Taegun ParkIntegrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.
Eunyoung KimIntegrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.
Seunggwan LeeIntegrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.
Korea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-NaCl diet is a contributing factor for cardiac hypertrophy. The role of HSP22 as a protective protein during cardiac hypertrophy due to hypernatremia is unclear. Accordingly, this study aimed to establish a cellular hypernatremic H9C2 model and to compare the expression of HSP22 in Ca

methodsReal-time PCR was performed to compare the mRNA expression. Flow cytometry and confocal microscopy were used to analyze the cells.

resultsThe addition of 30 mM NaCl for 48 h was the most effective condition for the induction of hypertrophic H9C2 cells (termed the

conclusionThe results showed that NaCl significantly decreased HSP22. Decreased HSP22, due to the hypernatremic condition, affected the Ca

Indexed as

Cardiac hypertrophyHomeostasisHSP22 proteinLate embryogenesis abundant protein

Identifiers

PMID30046328
PMCPMC6051945
OpenAlexW2883786295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.