ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2018
Hypoglycemic activity and constituents analysis of blueberry (
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of methyl Jasmonate on blueberry ripening fruits: assessment of cell wall thermal stability, nutritional parameters and antioxidant enzymatic activity.Frontiers in plant science · 2025Article
- Evaluation of Hypoglycemic Polyphenolic Compounds in Blueberry Extract: Functional Effects and Mechanisms.Antioxidants (Basel, Switzerland) · 2024Article
- The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia.Nutrients · 2024Review
- Biochemical Evaluation of Some Fruit Characteristics of Blueberry Progenies Obtained from 'Simultan × Duke'.ACS omega · 2023Article
- Hydroethanolic Extract ofMolecules (Basel, Switzerland) · 2022Article
- Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression.Antioxidants (Basel, Switzerland) · 2021Review
- Caffeoylquinic Acid Derivatives of Purple Sweet Potato as Modulators of Mitochondrial Function in Mouse Primary Hepatocytes.Molecules (Basel, Switzerland) · 2021Article
- Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications.Nutrients · 2020Review
- A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated fromInternational journal of molecular sciences · 2020Article
- Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse.Nutrition & metabolism · 2019Article
- Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate hypoglycemic activity and elucidate the active composition of the fruit blueberry (
methodsMethanol extracts of blueberry (MEB) were separated using a D101 macroporous resin column to yield quinic acid derivative (Fr.1)- and flavonoid (Fr.2)-rich fractions. The effects of the blueberry extracts on mRNA expression of GLUT-2 (glucose transporter type 2) and PPARγ (peroxisome proliferator-activated receptor-γ), as well as on the activities of PPRE (peroxisome proliferator response element) and NF-κB were analyzed in LO2 normal liver cells. Real-time PCR was used to detect the expression of GLUT-2, PPARγ, TNF-α, IL-1β, and IL-6 mRNA. The PPRE and NF-κB activities were detected by a luciferase reporter assay. Western blotting was used to detect the levels of PPARγ, GLUT-2, and p65. The active compositions were isolated using various chromatography columns, and were analyzed by NMR.
resultsmRNA and protein expression of GLUT-2 and PPARγ were significantly increased upon treatment with 400 μg/mL extracts of blueberry (
conclusionBlueberry may have hypoglycemic activity that functions through synergistic effects with caffeoylquinic acid derivatives and quercetin glycosides.
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Registered trials
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