ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2018
Presence of circulating tumor cells is associated with metabolic-related variables in postoperative patients with early-stage breast cancer.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status.Cellular and molecular bioengineering · 2023Article
- A nomogram for predicting the HER2 status of circulating tumor cells and survival analysis in HER2-negative breast cancer.Frontiers in oncology · 2022Article
- A fluorescent immunosensor for determination and imaging of circulating tumor cells based on a bifunctional DNA nanomachine.Mikrochimica acta · 2020Article
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8 authors.
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Abstract
objectiveAlthough circulating tumor cells (CTCs) have been well-established as promising prognostic biomarkers in both early breast cancer and metastatic settings, little is known regarding the prognostic relevance of CTCs in the long-term postoperative monitoring of patients with non-metastatic breast cancer (non-MBC). In this study, we investigated the associations of CTCs with clinicopathological features and metabolic-related variables, such as obesity and hyperglycemia.
methodsIn this retrospective study, we recruited 264 patients with postoperative stage I-III breast cancer at Guangdong General Hospital from January 2009 to December 2015. The prevalence and number of CTCs were assessed using the CellSearch System at a median time of 19.0 months [interquartile range (IQR), 7.8-33.0] after surgery. The CTC assay results were correlated with the clinicopathological features and metabolic-related variables. A multivariate logistic regression analysis was performed to further determine the independent predictors of CTCs.
resultsCTCs were detected in 10.6% of all patients. The positive rate of CTCs in patients with infiltrating ductal carcinoma was lower than that in patients with other pathological types (9.0%
conclusionsThis study revealed potential associations between CTCs and metabolic-related factors in Chinese patients with non-MBC and supports the hypothesis that metabolic dysfunction in breast cancer patients might influence the biological activity of metastatic breast cancer, leading to a higher prevalence of CTCs.
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