Evidence map›Paper›PMID 30046227›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2018

Treatment patterns for adjuvant docetaxel-based chemotherapy in early-stage breast cancer in China: A pooled retrospective analysis of four observational studies.

Binghe Xu, Zhimin Shao, Shui Wang, Zefei Jiang, Xichun Hu, Xiaohua Zhang, Xiru Li, Jinping Liu, Mengquan Li, Shu Wang

Abstract read
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Binghe XuNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhimin ShaoFudan University Shanghai Cancer Hospital, Shanghai 200032, China.
Shui WangJiangsu Province Hospital, Nanjing 210029, China.
Zefei JiangAffiliated Hospital of Chinese Academy of Military Medical Sciences, Beijing 100071, China.
Xichun HuFudan University Shanghai Cancer Hospital, Shanghai 200032, China.
Xiaohua Zhangthe First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xiru LiDivision of Breast Surgery, Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Jinping LiuSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Mengquan Lithe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Shu WangPeking University People's Hospital, Beijing 100044, China.
First Affiliated Hospital of Zhengzhou University · CNAcademy of Military Medical Sciences · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Wenzhou Medical University · CNFudan University Shanghai Cancer Center · CNJiangsu Province Hospital · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdjuvant docetaxel-based chemotherapy is frequently used for operable early breast cancer (EBC). This study investigated patterns of use of docetaxel (T) in real-life clinical practice in China.

methodsThis was a retrospective pooled analysis of the Asia-Pacific Breast Initiatives (APBI) I (2006-2008) and II (2009-2011) registries, and two Chinese observational studies; BC STATE (2011-2014) and BC Local Registry (2007-2010). Female Chinese adults (≥18 years) with operable breast cancer treated with docetaxel-based adjuvant chemotherapy were included in the analysis. Patients with metastatic disease were excluded. The primary endpoint was assessment of treatment patterns and patient profiles. A logistic regression analysis was conducted to identify factors associated with choice of adjuvant chemotherapy regimen.

resultsData from 3,020 patients were included. The most frequently used adjuvant regimen was docetaxel/anthracycline combination [n=1,421 (47.1%); of whom 52.0% received T/epirubicin (E)/cyclophosphamide (C)], followed by docetaxel/other [n=705 (23.3%); of whom 72.8% received TC], docetaxel/anthracycline sequential [n=447 (14.8%); of whom 40.9% and 39.6% received 5-Fu/EC-T and EC-T, respectively], and " other" [n=447 (14.8%); of whom 91.5% received T]. A significant association was found between adjuvant therapy with docetaxel/anthracycline combination and patient weight, menopausal status and estrogen receptor status.

conclusionsReal-world data revealed that docetaxel/anthracycline combination is the most commonly used category of docetaxel-based adjuvant therapy for patients with operable breast cancer in China; of which TEC is the most frequently used regimen.

Indexed as

Adjuvant chemotherapydocetaxelearly-stage breast cancer

Identifiers

PMID30046227
PMCPMC6037591
OpenAlexW2822237153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.