Evidence map›Paper›PMID 30046180›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2018

Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors.

Michael W Gaynon, Ronald J Wong, David K Stevenson, Philip Sunshine

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A clinician's musings on oxygen: Too little or too much with life in the balance.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  2. Article
  3. Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael W GaynonByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA. gaynon@stanford.edu.
Ronald J WongDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Philip SunshineDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduced in preterm infants by modifying certain systemic factors. There are steps that can be taken both early and late in the course of retinal vascular maturation that may potentially reduce an infant's risk of developing Type 1 ROP. In prethreshold stage 2-3 ROP without plus disease, a combination of supplemental oxygen, correction of severe anemia, and light adaptation to reduce rod photoreceptor oxygen consumption helped us to reduce ROP severity, and encouraged a return to a more physiologic retinal vascular maturation pattern. Thus, it may be possible to reduce the risk of developing Type 1 ROP by making adjustments in certain systemic parameters aimed at reducing retinal hypoxia, thereby gently lowering pathologically elevated levels of vascular endothelial growth factor (VEGF) within the eye.

Indexed as

Adaptation, OcularAnemiaBlindnessHumansInfantInfant, NewbornNutritional StatusOxygenOxygen ConsumptionOxygen Inhalation TherapyRetinopathy of PrematurityTime FactorsVascular Endothelial Growth Factor AOxygenVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID30046180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.