ArticleScientific reports2018
Overexpression of Tisochrysis lutea Akd1 identifies a key cold-induced alkenone desaturase enzyme.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- New genomic insights into long-chain alkenone biosynthesis by the coccolithophorid marine alga Gephyrocapsa huxleyi.BMC genomics · 2026Article
- Article
- Comprehensive identification and subcellular localization prediction of carbonic anhydrases in the marine haptophyte Tisochrysis lutea based on a refined genome annotation.Archives of microbiology · 2026Article
- Characterization of fucoxanthin-deficient strains in the haptophyte Tisochrysis lutea induced by heavy-ion beam irradiation.Plant & cell physiology · 2026Article
- Characterization of Delta-7 Alkenone Desaturase in Haptophyte Gephyrocapsa huxleyi Through Heterologous Expression in Tisochrysis lutea.Marine biotechnology (New York, N.Y.) · 2025Article
- Encapsulation of MicroalgaeMarine drugs · 2024Article
- Association of Phosphatidylinositol-Specific Phospholipase C with Calcium-Induced Biomineralization in the CoccolithophoreMicroorganisms · 2020Article
- Article
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5 authors.
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Abstract
Alkenones are unusual long-chain neutral lipids that were first identified in oceanic sediments. Currently they are regarded as reliable palaeothermometers, since their unsaturation status changes depending on temperature. These molecules are synthesised by specific haptophyte algae and are stored in the lipid body as the main energy storage molecules. However, the molecular mechanisms that regulate the alkenone biosynthetic pathway, especially the low temperature-dependent desaturation reaction, have not been elucidated. Here, using an alkenone-producing haptophyte alga, Tisochrysis lutea, we show that the alkenone desaturation reaction is catalysed by a newly identified desaturase. We first isolated two candidate desaturase genes and found that one of these genes was drastically upregulated in response to cold stress. Gas chromatographic analysis revealed that the overexpression of this gene, named as Akd1 finally, increased the conversion of di-unsaturated C
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