ArticleScientific reports2018
Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Developmental responses of sterlet (Acipenser ruthenus) to temperature modulation with insights into intestinal and morphological traits.Scientific reports · 2025Article
- Innovative Protein Ingredients for Feeding Gilthead Seabream (Aquaculture nutrition · 2025Article
- Water temperature modulates multidimensional plastic responses to water flow during the ontogeny of a neotropical fish (Frontiers in cell and developmental biology · 2025Article
- The Pattern of Gene Expression (Animals : an open access journal from MDPI · 2024Article
- Effects of the Interaction between Dietary Vitamin DAnimals : an open access journal from MDPI · 2024Article
- Skeletal Morphogenesis and Anomalies in Gilthead Seabream: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Recent advances in the crosstalk between adipose, muscle and bone tissues in fish.Frontiers in endocrinology · 2023Review
- Muscle regeneration in gilthead sea bream: Implications of endocrine and local regulatory factors and the crosstalk with bone.Frontiers in endocrinology · 2023Article
- Hydroxytyrosol-rich extract from olive juice as an additive in gilthead sea bream juveniles fed a high-fat diet: Regulation of somatic growth.Frontiers in physiology · 2022Article
- Musculoskeletal Growth Modulation in Gilthead Sea Bream Juveniles Reared at High Water Temperature and Fed with Palm and Rapeseed Oils-Based Diets.Animals : an open access journal from MDPI · 2021Article
- Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream.Scientific reports · 2020Article
- Temperature Affects Musculoskeletal Development and Muscle Lipid Metabolism of Gilthead Sea Bream (Frontiers in endocrinology · 2019Article
- Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature. The impact of a temperature drop from 23 to 13 °C was evaluated in juvenile fish thermally imprinted during embryogenesis. Both, in vitro/in vivo, Fib1a, appeared important in the first stages of bone formation, and Col1A1, ON and OP, in regulating matrix production and mineralization. OCN mRNA levels were up-regulated in the final larval stages when mineralization was more intense. Moreover, temperature-dependent differential gene expression was observed, with lower transcript levels in the larvae at 18 °C relative to those at 22 °C, suggesting bone formation was enhanced in the latter group. Results revealed that thermal imprinting affected the long-term regulation of osteogenesis. Specifically, juveniles under the low and low-to-high-temperature regimes had reduced levels of OCN when challenged, indicative of impaired bone development. In contrast, gene expression in fish from the high and high-to-low-temperature treatments was unchanged, suggesting imprinting may have a protective effect. Overall, the present study revealed that thermal imprinting modulates bone development in seabream larvae, and demonstrated the utility of the in vitro MSC culture as a reliable tool to investigate fish osteogenesis.
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