Evidence map›Paper›PMID 30046110›Full record

ArticleNature2018

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Hind Ghezraoui, Catarina Oliveira, Jordan R Becker, Kirstin Bilham, Daniela Moralli, Consuelo Anzilotti, Roman Fischer, Mukta Deobagkar-Lele, Maria Sanchiz-Calvo, Elena Fueyo-Marcos and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 315 citations in OpenAlex.

  1. Mechanisms and disease relevance of DNA break repair pathway choice.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. CHAMP1 complex promotes heterochromatin assembly and reduces replication stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Hind GhezraouiGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Catarina OliveiraGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Jordan R BeckerGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Kirstin BilhamGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Daniela MoralliChromosome Dynamics, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Consuelo AnzilottiMRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Roman FischerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Mukta Deobagkar-LeleMRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Maria Sanchiz-CalvoGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Elena Fueyo-MarcosGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Sarah BonhamTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Benedikt M KesslerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Sven RottenbergInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Richard J CornallMRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Catherine M GreenChromosome Dynamics, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
J Ross ChapmanGenome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. rchapman@well.ox.ac.uk.
University of Oxford · GBCentre for Human Genetics · GBMRC Human Immunology Unit · GBUniversity of Bern · CH

Funding

Cancer Research UK 19270Cancer Research UK A19270Medical Research Council MC_UU_00008/6Medical Research Council MR/M009971/1Medical Research Council MR/R017549/1Wellcome Trust 090532
6 · The paper itself

Abstract

53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination

Indexed as

DNA End-Joining RepairAnimalsCell Cycle ProteinsCell LineDNADNA-Binding ProteinsDNA Breaks, Double-StrandedDNA, Single-StrandedFemaleHumansImmunoglobulin Class SwitchingMad2 ProteinsMaleMiceMice, Inbred C57BLMultiprotein ComplexesCell Cycle ProteinsDNADNA-Binding ProteinsDNA, Single-StrandedMad2l2 protein, mouseMad2 ProteinsMultiprotein ComplexesShld1 protein, mouseShld2 protein, mouseShld3 protein, mouseTrp53bp1 protein, mouseTumor Suppressor p53-Binding Protein 1

Identifiers

PMID30046110
PMCPMC6989217
OpenAlexW2884164644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.