ArticleNature2018
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
Abstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 2 pooled it
13.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 2 syntheses or guidelines pooled it, 225 citations in OpenAlex.
- Chemical Inhibition of Sterol Biosynthesis.Biomolecules · 2024Pooled it
- Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets.International journal of molecular sciences · 2023Pooled it
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- A novel small molecule remyelination therapy for multiple sclerosis.npj drug discovery · 2026Article
- Mass Spectrometry-Based Screening Reveals Inhibitors of Cholesterol 25-Hydroxylase.ACS chemical biology · 2026Article
- MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway.iScience · 2026Article
- Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026Article
- Modulation of the unfolded protein response with a C-terminal fragment of MANF facilitates recovery in models of multiple sclerosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Suppression of 6-pyruvoyl-tetrahydropterin synthase promotes remyelination in multiple sclerosis.BMC medicine · 2025Article
- Targeted regulation of sterol biosynthesis genes according to perturbations in ergosterol biosynthesis in fungi.Journal of advanced research · 2025Article
- Review
- Combination therapy dramatically promotes remyelination.Journal of molecular cell biology · 2025Article
- Altered Lipid Metabolism in CNS Demyelination and Remyelination Are Key Elements Driving Progressive MS.International journal of molecular sciences · 2025Review
- Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025Review
- CYP51A1 in health and disease: from sterol metabolism to regulated cell death.Cell death discovery · 2025Review
- Current Development of iPSC-Based Modeling in Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- An In Silico Study on Withania somnifera Bioactives and Curcumin Analogs as Potential Inducers of Smoothened (Smo) Receptor of Sonic Hedgehog (SHH) Pathway to Promote Oligodendrogenesis.Molecular neurobiology · 2025Article
- Myelin ensheathment and drug responses of oligodendrocytes are modulated by stiffness of artificial axons.PloS one · 2025Article
- Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses.Aging and disease · 2024Review
- Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair.Nature communications · 2024Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 3 countries.
Zita HublerDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Dharmaraja AllimuthuDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Ilya BedermanDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Matthew S ElittDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Mayur MadhavanDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Kevin C AllanDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
H Elizabeth ShickDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Eric GarrisonDepartment of Anatomy and Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Molly T KarlDepartment of Anatomy and Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Daniel C FactorDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Zachary S NevinDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Joel L SaxDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Matthew A ThompsonDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Yuriy FedorovSmall Molecule Drug Development Core, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jing JinDepartment of BioSciences, Rice University, Houston, TX, USA.
William K WilsonDepartment of BioSciences, Rice University, Houston, TX, USA.
Martin GieraLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Franz BracherDepartment of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Munich, Germany.
Robert H MillerDepartment of Anatomy and Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Paul J TesarDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Drew J AdamsDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA. drew.adams@case.edu.
Case Western Reserve University · USUniversity School · USGeorge Washington University · USRice University · USLudwig-Maximilians-Universität München · DENetherlands Metabolomics Centre · NL
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MResearch_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI JAISWAL, JYOTI K · 2016 to 2020
$5.9MNRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9MDrug-mediated enhancement of myelinationR01NS095280 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MILLER, ROBERT H., TESAR, PAUL JOSEPH · 2015 to 2019
$1.9MAcquisition of a Leica TCS SP5 Confocal Microscope For A Multi-User FacilityS10OD016164 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CONRAD, PATRICIA A · 2013 to 2013
$597kNovel targets in the cholesterol biosynthesis pathway for enhanced oligodendrocyte formationF30MH116581 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI HUBLER, ZITA MARIA LUPE · 2018 to 2021
$195kNCATS NIH HHS TL1 TR002549NCI NIH HHS P30 CA043703NICHD NIH HHS U54 HD090257NIGMS NIH HHS T32 GM007250NIH HHS S10 OD016164NIMH NIH HHS F30 MH116581NINDS NIH HHS R01 NS095280
Abstract
Regeneration of myelin is mediated by oligodendrocyte progenitor cells-an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS underlies a number of neurological diseases, including multiple sclerosis and diverse genetic diseases
Indexed as
Remyelination14-alpha Demethylase InhibitorsAnimalsCholesterolHEK293 CellsHigh-Throughput Screening AssaysHumansImidazolesMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisMyelin SheathOligodendrogliaOxidoreductases Acting on CH-CH Group Donors14-alpha Demethylase InhibitorsCholesterolImidazolesMembrane ProteinsOxidoreductases Acting on CH-CH Group DonorsSteroid IsomerasesSterol 14-DemethylaseSterolsTM7SF2 protein, human
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.