ArticleScientific reports2018
Decreased Chromosomal Damage in Lymphocytes of Obese Patients After Bariatric Surgery.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Prediction of postoperative infection through early-stage salivary microbiota following kidney transplantation using machine learning techniques.Renal failure · 2025Article
- The dual nature of DNA damage response in obesity and bariatric surgery-induced weight loss.Cell death & disease · 2024Article
- Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Obesity-related genomic instability and altered xenobiotic metabolism: possible consequences for cancer risk and chemotherapy.Expert reviews in molecular medicine · 2022Review
- Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome.Metabolites · 2022Article
- Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR.iScience · 2020Article
- Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases.Scientific reports · 2020Article
- Article
- Obesity, DNA Damage, and Development of Obesity-Related Diseases.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of bariatric surgeries being performed worldwide has markedly risen. While the improvement in obesity-associated comorbidities after bariatric surgery is well-established, very little is known about its impact on cancer risk. The peripheral lymphocyte micronucleus test is a widely used method for the monitoring of chromosomal damage levels in vivo, and micronucleus frequency positively correlates with cancer risk. Therefore, the aim of this study was to compare the micronucleus frequency before and after bariatric surgery in obese subjects. Peripheral blood mononuclear cells were collected from 45 obese subjects before and at two time-points after bariatric surgery (6 and 12 months) to assess spontaneous micronucleus frequency. Consistent with the increased cancer risk previously shown, bariatric surgery-induced weight loss led to a significant reduction in lymphocyte micronucleus frequency after 12 months. Interestingly, comorbidities such as type 2 diabetes mellitus and metabolic syndrome further seemed to have an impact on the lymphocyte micronucleus frequency. Our findings may indicate a successful reduction of cancer risk in patients following weight loss caused by bariatric surgery.
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