Evidence map›Paper›PMID 30046033›Full record

SynthesisNature communications2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Jessica van Setten, Jennifer A Brody, Yalda Jamshidi, Brenton R Swenson, Anne M Butler, Harry Campbell, Fabiola M Del Greco, Daniel S Evans, Quince Gibson, Daniel F Gudbjartsson and 116 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 6 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Wavelet Decomposition-Based Genomic Analysis of the Human Electrocardiogram.medRxiv : the preprint server for health sciences · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  18. Article
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  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

126 authors at 20 institutions in 11 countries.

Jessica van SettenDepartment of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, 3584CX, The Netherlands. J.vanSetten@umcutrecht.nl.ORCID http://orcid.org/0000-0002-4934-7510
Jennifer A BrodyDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, 98195, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Yalda JamshidiCardiogenetics Lab, Molecular and Clinical Sciences Research Institute, St George's University of London, London, SW17 0RE, UK.
Brenton R SwensonDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, 98195, WA, USA.
Anne M ButlerDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9YL, UK.
Fabiola M Del GrecoInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, 94107, CA, USA.
Quince GibsonDepartment of Surgery, University of Alabama Birmingham Hospital, Birmingham, 35233, AL, USA.
Daniel F GudbjartssondeCODE genetics/Amgen, Inc., Reykjavik, IS-101, Iceland.
Kathleen F KerrDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, 98195, WA, USA.ORCID http://orcid.org/0000-0002-6438-9583
Bouwe P KrijtheDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Christian MüllerDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, 20251, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany.ORCID http://orcid.org/0000-0003-3793-5910
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713GZ, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, Scotland, UK.
Marylyn D RitchieDepartment of Genetics, University of Pennsylvania, Philadelphia, PA 19104, PA, USA.ORCID http://orcid.org/0000-0002-1208-1720
Antonietta RobinoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Albert V SmithIcelandic Heart Association, Kopavogur, IS-201, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Maristella SteriIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, 00185, Cagliari, Italy.ORCID http://orcid.org/0000-0001-5869-3872
Toshiko TanakaTranslational Gerontology Branch, NIA, Baltimore, 20892, MD, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17489, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
Sheila UliviInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, 7913GZ, The Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
Xiaoyan YinDepartment of Medicine, Boston University School of Medicine, Boston, 02118, MA, USA.
David O ArnardeCODE genetics/Amgen, Inc., Reykjavik, IS-101, Iceland.
Folkert W AsselbergsDepartment of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, 3584CX, The Netherlands.ORCID http://orcid.org/0000-0002-1692-8669
Joel S BaderDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, 21218, MD, USA.ORCID http://orcid.org/0000-0002-6020-4625
John BarnardDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, 44195, OH, USA.
Josh BisDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, 20251, Germany.
Stefan BlankenbergDZHK (German Center for Cardiovascular Research) Partner Site, Hamburg/Kiel/Lübeck, Germany.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Yuki BradfordDepartment of Genetics, University of Pennsylvania, Philadelphia, PA 19104, PA, USA.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, T12 K8AF, Ireland.
Mina K ChungDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, 44195, OH, USA.
Dana CrawfordInstitute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
Marcel den HoedDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SE-751 05, Sweden.
Josh C DennyBiomedical Informatics and Medicine, Vanderbilt University, Nashville, 37235, TN, USA.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, Scotland, UK.ORCID http://orcid.org/0000-0003-4913-3608
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.ORCID http://orcid.org/0000-0002-5730-0675
Mark EijgelsheimDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
Patrick T EllinorProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Stephan B FelixDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475, Greifswald, Germany.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 7913GZ, The Netherlands.ORCID http://orcid.org/0000-0002-5159-8802
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, 20892, MD, USA.
Hilma HolmdeCODE genetics/Amgen, Inc., Reykjavik, IS-101, Iceland.
Gandin IlariaDepartment of Medical Sciences, University of Trieste, Trieste, 34127, Italy.
Annamaria IorioCardiovascular Department, "Ospedali Riuniti and University of Trieste", Trieste, 34124, Italy.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.
Ivana KolcicFaculty of Medicine, University of Split, Split, 21000, Croatia.
Jan A KorsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, 20892, MD, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, 20892, MD, USA.
Honghuang LinDepartment of Medicine, Boston University School of Medicine, Boston, 02118, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Henry J LinThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Steven A LubitzProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.
Peter W MacfarlaneInstitute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Jared W MagnaniDepartment of Medicine, Division of Cardiology, University of Pittsburgh Medical Center Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, 15260, PA, USA.
Irene Mateo LeachDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, 7913GZ, The Netherlands.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 80802, Germany.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, 21201, MD, USA.
Thomas MunzelCenter for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, Germany.ORCID http://orcid.org/0000-0001-5503-4150
George J PapanicolaouDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, 20892, MD, USA.
Annette PetersDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 80802, Germany.
Arne PfeuferMVZ für Molekulardiagnostik, Munich, 81543, Germany.
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
Jerome I RotterDepartments of Medicine and Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9YL, UK.ORCID http://orcid.org/0000-0001-6993-6884
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, LE1 7RH, UK.
David SchlessingerLaboratory of Genetics and Genomics, National Institute on Aging, National Institute of Health, Baltimore, 20892, MD, USA.
Claudia T Silva AldanaGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Moritz F SinnerDepartment of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, 81377, Germany.
Jonathan D SmithDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, 44195, OH, USA.ORCID http://orcid.org/0000-0002-0415-386X
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713GZ, The Netherlands.
Elsayed Z SolimanEpidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, 27101, NC, USA.ORCID http://orcid.org/0000-0001-5632-8150
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital, King's College London, London, WC2R 2LS, UK.
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, Scotland, UK.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Kirill V TarasovLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, 20892, MD, USA.ORCID http://orcid.org/0000-0001-7799-4670
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Inc., Reykjavik, IS-101, Iceland.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
David R Van WagonerDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, 44195, OH, USA.ORCID http://orcid.org/0000-0001-8250-9828
Uwe VölkerDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475, Greifswald, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17489, Germany.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 80802, Germany.
Harm Jan WestraDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 7913GZ, The Netherlands.ORCID http://orcid.org/0000-0001-7038-567X
Philipp S WildDZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, 55131, Germany.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, 20251, Germany.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.ORCID http://orcid.org/0000-0002-2225-8323
Christy L AveryDepartment of Epidemiology and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, 50122, Italy.
Emelia J BenjaminDurrer Center for Cardiogenetic Research, Netherlands Heart Institute, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-4076-2336
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, 00185, Cagliari, Italy.ORCID http://orcid.org/0000-0002-7414-1995
Marcus DörrDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475, Greifswald, Germany.
Luigi FerrucciTranslational Gerontology Branch, NIA, Baltimore, 20892, MD, USA.
Paolo GaspariniInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, IS-201, Iceland.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK.ORCID http://orcid.org/0000-0002-9405-9550
Susan R HeckbertCardiovascular Health Research Unit and the Department of Epidemiology, University of Washington, Seattle, 98195, WA, USA.
Andrew A HicksInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.ORCID http://orcid.org/0000-0001-6320-0411
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Stefan KääbDepartment of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, 81377, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, 27101, NC, USA.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0002-4176-2947
Afshin ParsaDepartment of Medicine, University of Maryland School of Medicine and Baltimore VA Medical Center, Baltimore, 21201, MD, USA.
Ozren PolasekFaculty of Medicine, University of Split, Split, 21000, Croatia.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, 98195, WA, USA.
Dan M RodenMedicine, Pharmacology, and Biomedical Informatics, Vanderbilt University, Nashville, 37235, TN, USA.
Renate B SchnabelDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, 20251, Germany.
Gianfranco SinagraCardiovascular Department, "Ospedali Riuniti and University of Trieste", Trieste, 34124, Italy.ORCID http://orcid.org/0000-0003-2700-8478
Kari StefanssondeCODE genetics/Amgen, Inc., Reykjavik, IS-101, Iceland.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, 7913GZ, The Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
James F WilsonCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9YL, UK.ORCID http://orcid.org/0000-0001-5751-9178
Sina A GharibCardiovascular Health Research Unit, Division of Pulmonary Critical Care and Sleep Medicine, Computational Medicine Core at Center for Lung Biology, Department of Medicine, University of Washington, Seattle, 98195, WA, USA.
Paul I W de BakkerDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands.
Aaron IsaacsCARIM School for Cardiovascular Diseases, Maastricht, 6229ER, The Netherlands.ORCID http://orcid.org/0000-0001-5037-4834
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
Nona SotoodehniaDepartments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA. nsotoo@u.washington.edu.
University Medical Center Groningen · NLErasmus MC · NLUniversity of Washington · USUniversitätsmedizin Greifswald · DEdeCODE Genetics (Iceland) · ISHelmholtz Zentrum München · DENational Institutes of Health · USUniversität Hamburg · DEUniversity of Glasgow · GBUniversity of Trieste · ITBoston University · USCleveland Clinic · USEurac Research · ITJohns Hopkins University · USBroad Institute · USGerman Centre for Cardiovascular Research · DEInstitute of Genetic and Biomedical Research · ITInstitute of Genetics and Cancer · GBIRCCS Materno Infantile Burlo Garofolo · ITJohannes Gutenberg University Mainz · DE

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Functional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
The Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Genetics of Atrial FibrillationR01HL090620 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2008 to 2012
$2.9M
Genomics of Cardiac Electrical Activity and ArrhythmiaR01HL116747 · NHLBI · UNIVERSITY OF WASHINGTON · PI ARKING, DAN E, SOTOODEHNIA, NONA · 2013 to 2016
$2.8M
The InChianti StudyZIAAG001050 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$2.1M
Medical Research Council MC_UU_00007/10NHLBI NIH HHS K23 HL114724NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL139731NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS U24 AG051129NICHD NIH HHS P2C HD050924
6 · The paper itself

Abstract

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.

Indexed as

Genome-Wide Association StudyAtrial FunctionAtrioventricular NodeElectrocardiographyElectrophysiological PhenomenaFemaleHumansLinkage DisequilibriumMaleMutation, MissenseRisk Factors

Identifiers

PMID30046033
PMCPMC6060178
OpenAlexW2883497414

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