ArticlePharmacy (Basel, Switzerland)2018
Polypharmacy and Medication-Related Problems in Hemodialysis Patients: A Call for Deprescribing.
Article in Pharmacy (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05585268 (Electronic Decision Support for Deprescribing in Patients on Hemodialysis), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electronic Decision Support for Deprescribing in Patients on Hemodialysis: a Prospective, Controlled, Quality Improvement Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Clinical pharmacy practice in the care of Chronic Kidney Disease patients: a systematic review.International journal of clinical pharmacy · 2019Pooled it
- Nephrotoxic medication burden and drug-related problems in patients with chronic kidney disease using SGLT2 inhibitors.Renal failure · 2026Observational
- Recognizing the Elephant in the Room: High Arrhythmia Risk in Hemodialysis Patients' Prescriptions.Cureus · 2026Article
- A Qualitative Study to Investigate the Nutrition Perspectives and Experiences of Veterans with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Prevalence of potentially inappropriately prescribed medications among older adults receiving peritoneal dialysis.Pharmacotherapy · 2025Article
- Impact of pharmacist-led medication review among hemodialysis patients: a systematic review.Journal of pharmaceutical policy and practice · 2025Article
- Optimizing use of an electronic medical record system for quality improvement initiatives in hemodialysis: Review of a single center experience.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Review
- Article
- Clinical Pertinence and Determinants of Potential Drug-Drug Interactions in Chronic Kidney Disease Patients: A Cross-sectional Study.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Article
- Factors Contributing to Negative Outcomes Associated with Medications and Drug-Related Problems in Kidney Replacement Therapy-A Hospital-Based Prospective Observational Study.Journal of clinical medicine · 2024Article
- Polypharmacy and Quality of Life Among Dialysis Patients: A Qualitative Study.Kidney medicine · 2024Article
- Are Saudi Arabian Patients Willing to Be Deprescribed Their Medications? An Exploratory Study.Patient preference and adherence · 2024Article
- Review
- Effect of medication therapy management services on medication-burden quality of life in hemodialysis patients.BMC nephrology · 2023Article
- Medication Review with Follow-Up for End-Stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated with Medication-A Systematic Review.Journal of clinical medicine · 2023Review
- Association of Potentially Inappropriate Medication Classes with Mortality Risk Among Older Adults Initiating Hemodialysis.Drugs & aging · 2023Article
- Association of secondary prevention medication use after myocardial infarction with mortality in hemodialysis patients.Clinical kidney journal · 2022Article
- The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit.Medicina (Kaunas, Lithuania) · 2022Observational
- Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient.Frontiers in psychiatry · 2022Review
- Polypharmacy and medication use in patients with chronic kidney disease with and without kidney replacement therapy compared to matched controls.Clinical kidney journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polypharmacy is a common problem among hemodialysis patients. It is associated with increased hospital admissions, morbidity, mortality, Medication-Related Problems (MRPs), and expenditures. There is a paucity of data on the prevalence of polypharmacy in our setting. This study aims to determine the prevalence of polypharmacy and MRPs and to assess its predictors. We conducted a cross-sectional study in the outpatient hemodialysis unit. A pharmacy resident assessed electronic prescribing records to identify MRPs and discussed therapeutic interventions to enhance effective therapeutic regimens over a three months period. Eighty-three patients were included. The median age was 63 (Interquartile range; IQR = 22), 50% were males, and the mean number of co-morbidities was 3.14 ± 1.64. The prevalence of polypharmacy was 97.6% with a 95% CI (91.6%⁻99.7%). Medication use without indication, was the highest identified MRPs at 36% (102/280), followed by subtherapeutic dosing at 23% (65/280), and overdosing at 15% (41/280). The number of comorbidities, the presence of ischemic heart disease, and respiratory diseases were the main predictors of the increased number of medications. Polypharmacy is highly prevalent among the Saudi hemodialysis population. A review of the medications prescribed by the pharmacist facilitated the identification of MRPs and provided opportunities for deprescribing to optimize medication use and to reduce polypharmacy in hemodialysis patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.