Evidence map›Paper›PMID 30045987›Full record

ArticleJournal of virology2018

The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression.

Matthew R Pennington, Ian E H Voorhees, Heather M Callaway, Shannon D Dehghanpir, Joel D Baines, Colin R Parrish, Gerlinde R Van de Walle

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew R PenningtonBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Ian E H VoorheesBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Heather M CallawayBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Shannon D DehghanpirDepartment of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Joel D BainesDepartment of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID 0000-0002-6397-2830
Colin R ParrishBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-1836-6655
Gerlinde R Van de WalleBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA grv23@cornell.edu.
Cornell University · USLouisiana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alphaherpesvirus-associated ocular infections in humans caused by human alphaherpesvirus 1 (HHV-1) remain challenging to treat due to the frequency of drug application required and the potential for the selection of drug-resistant viruses. Repurposing on-the-market drugs is a viable strategy to accelerate the pace of drug development. It has been reported that the human immunodeficiency virus (HIV) integrase inhibitor raltegravir inhibits HHV-1 replication by targeting the DNA polymerase accessory factor and limits terminase-mediated genome cleavage of human betaherpesvirus 5 (HHV-5). We have previously shown, both

Indexed as

AnimalsCatsCell LineDNA-Binding ProteinsDNA, ViralGene Expression Regulation, ViralHIV Integrase InhibitorsRaltegravir PotassiumVaricellovirusViral ProteinsVirus ReplicationDNA-Binding ProteinsDNA, ViralHIV Integrase InhibitorsRaltegravir PotassiumViral ProteinsDNA replicationFeHV-1feline herpesvirusICP8late gene expressionraltegravirterminase

Identifiers

PMID30045987
PMCPMC6158441
OpenAlexW2883511819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.